BRAIN ANTIOXIDANT PROPERTIES OF PIPER CUBEBA L. EXTRACTS AND ESSENTIAL OIL

被引：3

作者：

Dwita, Lusi Putri ^{[1
,2
]}

Iwo, Maria Immaculata ^{[1
]}

Elfahmi ^{[1
]}

Mauludin, Rachmat ^{[1
]}

机构：

[1] Inst Teknol Bandung, Sch Pharm, Jl Ganesha 10, Bandung 40132, Jawa Barat, Indonesia

[2] Univ Muhammadiyah Prof DR HAMKA, Fac Pharm & Sci, Jakarta, Indonesia

来源：

FARMACIA | 2023年 / 71卷 / 02期

关键词：

Brain; antioxidant; Piper cubeba; SOD; CAT; MDA; NO; EXPRESSION;

D O I：

10.31925/farmacia.2023.2.9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study aimed to discover the antioxidant properties of Piper cubeba extract and essential oil in rats' brains. Antioxidant activity of P. cubeba's 96% ethanol extract (PC96), 70% ethanol extract (PC70), and essential oil (PO) was tested based on lipid peroxide, catalase (CAT), and superoxide dismutase (SOD) activities and nitric oxide (NO) concentration in the brain. The rats were given the samples for a week p.o, then the following day, the brain was collected. The metabolite content of the extract was analysed by Thin Layer Chromatography (TLC). The result showed that PC96, PC70, and PO could significantly inhibit the lipid peroxidase in rat's brain (p < 0.01). This activity was in line with the decrease in NO concentrations in all groups. However, there was no effect of P. cubeba on the SOD despite increased CAT activity. Overall, P. cubeba showed antioxidant activities in the brain, especially the 96% ethanol extract, therefore worth being developed as a neuroprotective agent.

引用

页码：296 / 302

页数：7

共 34 条

[1]

Abdul-Jalil TZ., 2020, INT J PHARM RES, V1, P761, DOI [10.31838/ijpr/2020.SP1.119, DOI 10.31838/IJPR/2020.SP1.119]

[2] Radical scavenging ability of some compounds isolated from Piper cubeba towards free radicals [J].

Aboul-Enein, Hassan Y. ;

Kladna, Aleksandra ;

Kruk, Irena .

LUMINESCENCE, 2011, 26 (03) :202-207

[3] Antioxidant Activities of a New Chemotype of Piper cubeba L. Fruit Essential Oil (Methyleugenol/Eugenol): In Silico Molecular Docking and ADMET Studies [J].

Alminderej, Fahad ;

Bakari, Sana ;

Almundarij, Tariq I. ;

Snoussi, Mejdi ;

Aouadi, Kaiss ;

Kadri, Adel .

PLANTS-BASEL, 2020, 9 (11) :1-18

[4] Therapeutic effects of eugenol in a rat model of traumatic brain injury: A behavioral, biochemical, and histological study [J].

Barot, Jeetprakash ;

Saxena, Bhagawati .

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE, 2021, 11 (04) :318-327

[5] Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach [J].

Behl, C ;

Moosmann, B .

FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (02) :182-191

[6] Neuroprotective effect of Artemisia absinthium L. on focal ischemia and reperfusion-induced cerebral injury [J].

Bora, Kundan Singh ;

Sharma, Anupam .

JOURNAL OF ETHNOPHARMACOLOGY, 2010, 129 (03) :403-409

[7] Effect of some medicinal plants on plasma antioxidant system and lipid levels in rats [J].

Choi, EM ;

Hwang, JK .

PHYTOTHERAPY RESEARCH, 2005, 19 (05) :382-386

[8] Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalis angulata and Rosa hybrida [J].

Choi, EM ;

Hwang, JK .

JOURNAL OF ETHNOPHARMACOLOGY, 2003, 89 (01) :171-175

[9]

Costea T, 2020, FARMACIA, V68, P1055

[10] Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke [J].

Davis, Stephanie M. ;

Pennypacker, Keith R. .

NEUROCHEMISTRY INTERNATIONAL, 2017, 107 :23-32

← 1 2 3 4 →