Integrative analysis of PTEN-related hub genes and validating drug targets for colorectal cancer

被引:0
作者
Wang, Gang [1 ,3 ]
Zhu, Zhi Min [1 ]
Wang, Kun [2 ]
机构
[1] Jiangsu Univ, Shanghai Peoples Hosp 8, Dept Pharmaceut, Shanghai, Peoples R China
[2] Jiangsu Univ, Dept Med, Zhenjiang, Jiangsu, Peoples R China
[3] Jiangsu Univ, Shanghai Peoples Hosp 8, Dept Pharmaceut, Shanghai 200235, Peoples R China
来源
PRECISION MEDICAL SCIENCES | 2024年 / 13卷 / 01期
基金
中国国家自然科学基金;
关键词
colorectal cancer; hub genes; individualized treatment; PTEN; TCGA; STANNIOCALCIN; 2; TUMOR-GROWTH; LAROTRECTINIB; EXPRESSION; PATHWAY; CELLS; CARCINOMA; BIOMARKER; STC2;
D O I
10.1002/prm2.12126
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Colorectal cancer (CRC) is a heterogeneous disease and one of the most prevalent malignancies worldwide. Previous research has indicated that phosphatase and tensin homolog (PTEN)-related genes found in CRC may serve as potential biomarkers for individualized treatment options. The present study aimed to examine the association between PTEN-related genes and the prognosis of CRC patients by evaluating the significance of PTEN-related hub genes and determining potential mechanisms and genes associated with them. Gene expression profiles and clinical information were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. At present, PTEN mutations have been identified in 7% of CRC patients, according to the most recent TCGA data. Differential expression analysis revealed 54 genes as differentially expressed genes (DEGs) between PTEN-related genes and GEO databases (GSE39582 and GSE6263). Further gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted on PTEN-related DEGs. The prognostic efficacy of the PTEN-related DEG signature was assessed using Kaplan-Meier survival and receiver operating characteristic curve analyses. Bioinformatics methods were utilized to analyze the correlation between PTEN-related DEGs and CRC prognosis, survival, and drug efficacy. Through these analyses, eight prognostic-related PTEN-related hub genes (PPARGC1A, NTRK2, ANK2, PLCB4, STC2, PLAU, CDKN1A, and HPGDS) were identified and a risk prognosis model was constructed. Notably, NTRK2 and HPGDS were found to affect drug treatment response in CRC. Targeting these prognostic-related PTEN-related hub genes can regulate cell death signaling, which may benefit the prognosis of CRC patients and improve drug sensitivity.
引用
收藏
页码:4 / 20
页数:17
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