From bottle to bedside: Implementation considerations and antimicrobial stewardship considerations for bloodstream infection rapid diagnostic testing

被引:7
作者
Lapin, Jonathan S. [1 ]
Smith, Richard D. [2 ]
Hornback, Krutika M. [3 ]
Johnson, J. Kristie [2 ]
Claeys, Kimberly C. [4 ,5 ]
机构
[1] Univ Maryland, Dept Pharm Practice, Med Ctr, Baltimore, MD USA
[2] Univ Maryland, Dept Pathol, Sch Med, Baltimore, MD USA
[3] Med Univ South Carolina MUSC Hlth, Dept Pharm Practice, Charleston, SC USA
[4] Univ Maryland, Dept Pharm Sci & Hlth Outcomes Res, Sch Pharm, Baltimore, MD USA
[5] Univ Maryland, Sch Pharm, 20 N Pine St, Baltimore, MD 21201 USA
来源
PHARMACOTHERAPY | 2023年 / 43卷 / 08期
关键词
antimicrobial stewardship; bloodstream infections; implementation; rapid diagnostics; DESORPTION IONIZATION-TIME; IN-SITU HYBRIDIZATION; CULTURE-IDENTIFICATION; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC STEWARDSHIP; IMPACT; INTERVENTION; OUTCOMES; SUSCEPTIBILITY; BACTEREMIA;
D O I
10.1002/phar.2813
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Antimicrobial stewardship (AMS) programs have been quick to adopt novel molecular rapid diagnostic technologies (mRDTs) for bloodstream infections (BSIs) to improve antimicrobial management. As such, most of the literature demonstrating the clinical and economic benefits of mRDTs for BSI is in the presence of active AMS intervention. Leveraging mRDTs to improve antimicrobial therapy for BSI is increasingly integral to AMS program activities. This narrative review discusses available and future mRDTs, the relationship between the clinical microbiology laboratory and AMS programs, and practical considerations for optimizing the use of these tools within a health system. Antimicrobial stewardship programs must work closely with their clinical microbiology laboratories to ensure that mRDTs are used to their fullest benefit while remaining cognizant of their limitations. As more mRDT instruments and panels become available and AMS programs continue to expand, future efforts must consider the expansion beyond traditional settings of large academic medical centers and how combinations of tools can further improve patient care.
引用
收藏
页码:847 / 863
页数:17
相关论文
共 83 条
[1]  
[Anonymous], CORE ELEMENTS HOSP A
[2]   Parallel Evaluation of the MALDI Sepsityper and Verigene BC-GN Assays for Rapid Identification of Gram-Negative Bacilli from Positive Blood Cultures [J].
Arroyo, Miguel A. ;
Denys, Gerald A. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2017, 55 (09) :2708-2718
[3]   Sustained impact of a rapid microarray-based assay with antimicrobial stewardship interventions on optimizing therapy in patients with Gram- positive bacteraemia [J].
Avdic, Edina ;
Wang, Ruibin ;
Li, David X. ;
Tamma, Pranita D. ;
Shulder, Stephanie E. ;
Carroll, Karen C. ;
Cosgrove, Sara E. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017, 72 (11) :3191-3198
[4]   Randomized Trial Evaluating Clinical Impact of RAPid IDentification and Susceptibility Testing for Gram-negative Bacteremia: RAPIDS-GN [J].
Banerjee, Ritu ;
Komarow, Lauren ;
Virk, Abinash ;
Rajapakse, Nipunie ;
Schuetz, Audrey N. ;
Dylla, Brenda ;
Earley, Michelle ;
Lok, Judith ;
Kohner, Peggy ;
Ihde, Sherry ;
Cole, Nicolynn ;
Hines, Lisa ;
Reed, Katelyn ;
Garner, Omai B. ;
Chandrasekaran, Sukantha ;
Maurice, Annabelle de St ;
Kanatani, Meganne ;
Curello, Jennifer ;
Arias, Rubi ;
Swearingen, William ;
Doernberg, Sarah B. ;
Patel, Robin .
CLINICAL INFECTIOUS DISEASES, 2021, 73 (01) :E39-E46
[5]   Rapid Antimicrobial Susceptibility Testing Methods for Blood Cultures and Their Clinical Impact [J].
Banerjee, Ritu ;
Humphries, Romney .
FRONTIERS IN MEDICINE, 2021, 8
[6]   Randomized Trial of Rapid Multiplex Polymerase Chain Reaction-Based Blood Culture Identification and Susceptibility Testing [J].
Banerjee, Ritu ;
Teng, Christine B. ;
Cunningham, Scott A. ;
Ihde, Sherry M. ;
Steckelberg, James M. ;
Moriarty, James P. ;
Shah, Nilay D. ;
Mandrekar, Jayawant N. ;
Patel, Robin .
CLINICAL INFECTIOUS DISEASES, 2015, 61 (07) :1071-1080
[7]  
Barlam TF, 2016, CLIN INFECT DIS, V62, pE51, DOI 10.1093/cid/ciw118
[8]   An Antimicrobial Stewardship Program's Impact with Rapid Polymerase Chain Reaction Methicillin- Resistant Staphylococcus aureus/S. aureus Blood Culture Test in Patients with S. aureus Bacteremia [J].
Bauer, Karri A. ;
West, Jessica E. ;
Balada-Llasat, Joan-Miquel ;
Pancholi, Preeti ;
Stevenson, Kurt B. ;
Goff, Debra A. .
CLINICAL INFECTIOUS DISEASES, 2010, 51 (09) :1074-1080
[9]   Usefulness of BioFire FilmArray BCID2 for Blood Culture Processing in Clinical Practice [J].
Berinson, Benjamin ;
Both, Anna ;
Berneking, Laura ;
Christner, Martin ;
Luetgehetmann, Marc ;
Aepfelbacher, Martin ;
Rohde, Holger .
JOURNAL OF CLINICAL MICROBIOLOGY, 2021, 59 (08)
[10]   Real-World Impact of the Accelerate PhenoTest BC Kit on Patients With Bloodstream Infections in the Improving Outcomes and Antimicrobial Stewardship Study: A Quasiexperimental Multicenter Study [J].
Bhalodi, Amira A. ;
MacVane, Shawn H. ;
Ford, Bradley ;
Ince, Dilek ;
Kinn, Patrick M. ;
Percival, Kelly M. ;
Bremmer, Derek N. ;
Carr, Dustin R. ;
Walsh, Thomas L. ;
Bhatti, Micah M. ;
Shelburne, Samuel A. ;
Humphries, Romney M. ;
Wolfe, Kaleb ;
Rosenbaum, Eric R. ;
Dare, Ryan K. ;
Kolev, Johann ;
Madhusudhan, Meghan ;
Ben-Aderet, Michael A. ;
Morgan, Margie A. .
CLINICAL INFECTIOUS DISEASES, 2022, 75 (02) :269-277