Performance of the fecal immunochemical test for colorectal cancer and advanced neoplasia in individuals under age 50

被引：3

作者：

Heer, Emily ^{[1
,2
]}

Ruan, Yibing ^{[2
,3
]}

Pader, Joy ^{[3
]}

Mah, Brittany ^{[2
]}

Ricci, Christina ^{[4
]}

Nguyen, Teresa ^{[2
]}

Chow, Kristian ^{[5
]}

Ford-Sahibzada, Chelsea ^{[2
]}

Gogna, Priyanka ^{[6
]}

Poirier, Abbey ^{[3
]}

Forbes, Nauzer ^{[1
,2
,7
]}

Heitman, Steve J. ^{[1
,2
,7
]}

Hilsden, Robert J. ^{[1
,2
,7
]}

Brenner, Darren R. ^{[2
,3
,5
,7
]}

机构：

[1] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada

[2] Univ Calgary, Forzani & MacPhail Colon Canc Screening Ctr, Calgary, AB, Canada

[3] Alberta Hlth Serv, Dept Canc Epidemiol & Prevent Res, Canc Control Alberta, Calgary, AB, Canada

[4] Publ Hlth Agcy Canada, Ottawa, ON, Canada

[5] Univ Calgary, Cumming Sch Med, Dept Oncol, Calgary, AB, Canada

[6] Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada

[7] Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB, Canada

来源：

PREVENTIVE MEDICINE REPORTS | 2023年 / 32卷

关键词：

Colorectal cancer; Cancer screening; Immunochemical; Fecal occult blood test; FIT;

D O I：

10.1016/j.pmedr.2023.102124

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The increased demand for colonoscopy combined with increased incidence of colorectal cancer (CRC) among younger populations presents a need to determine FIT performance among individuals in this age group. We conducted a systematic review to assess test performance characteristics of FIT in detecting CRC and advanced neoplasia in younger age populations. A search through December 2022 identified published articles assessing the sensitivity and specificity of FIT for advanced neoplasia or CRC among populations under age 50. Following the search, 3 studies were included in the systematic review. Sensitivity to detect advanced neoplasia ranged from 0.19 to 0.36 and specificity between 0.94 and 0.97 and the overall sensitivity and specificity were 0.23 (0.17-0.30) and 0.96 (0.94-0.98), respectively. Two studies that assessed these metrics in multiple age categories found similar sensitivity and specificity across all age groups 30-49. Sensitivity and specificity to detect CRC was assessed in one study and found no significant differences by age groups. These results suggest that FIT performance may be lower for younger individuals compared to those typically screened for CRC. However, there were few studies available for analysis. Given increasing recommendations to expand screening in younger age groups, more research is needed to determine whether FIT is an adequate screening tool in this population.

引用

页数：6