Focus on Anti-Tumour Necrosis Factor (TNF)-α-Related Autoimmune Diseases

被引：22

作者：

Lopetuso, Loris Riccardo ^{[1
,2
,3
]}

Cuomo, Claudia ^{[1
]}

Mignini, Irene ^{[1
]}

Gasbarrini, Antonio ^{[1
,4
]}

Papa, Alfredo ^{[1
,4
]}

机构：

[1] IRCCS, Ctr Diag & Treatment Digest Dis, Gastroenterol Dept, CEMAD,Fdn Policlin Gemelli, I-00168 Rome, Italy

[2] G DAnnunzio Univ Chieti Pescara, Dept Med & Ageing Sci, I-66100 Chieti, Italy

[3] G DAnnunzio Univ Chieti Pescara, Ctr Adv Studies & Technol CAST, I-66100 Chieti, Italy

[4] Catholic Univ, Sch Med, Dept Translat Med & Surg, I-00168 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 09期

关键词：

infliximab; adalimumab; etanercept; certolizumab pegol; golimumab; autoimmune diseases; inflammatory bowel disease; paradoxical reactions; ANTI-TNF-ALPHA; INFLAMMATORY-BOWEL-DISEASE; INFLIXIMAB-RELATED HEPATITIS; INTERSTITIAL LUNG-DISEASES; DRUG-INDUCED LUPUS; RHEUMATOID-ARTHRITIS; CROHNS-DISEASE; PULMONARY SARCOIDOSIS; FIBROSING ALVEOLITIS; ETANERCEPT THERAPY;

D O I：

10.3390/ijms24098187

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anti-tumour necrosis factor (TNF)-a agents have been increasingly used to treat patients affected by inflammatory bowel disease and dermatological and rheumatologic inflammatory disorders. However, the widening use of biologics is related to a new class of adverse events called paradoxical reactions. Its pathogenesis remains unclear, but it is suggested that cytokine remodulation in predisposed individuals can lead to the inflammatory process. Here, we dissect the clinical aspects and overall outcomes of autoimmune diseases caused by anti-TNF-a therapies.

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页数：13

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