Modulation of synaptic transmission through O-GlcNAcylation

被引：2
|
作者：
Han, Seunghyo [1 ]
Kim, Jun-Nyeong [1 ]
Park, Chan Ho [2 ]
Byun, Jin-Seok [3 ]
Kim, Do-Yeon [4 ]
Ko, Hyoung-Gon [1 ]
机构：
[1] Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Dent, Dept Anat & Neurobiol, 2177 Dalgubeol Daero, Daegu 41940, South Korea
[2] Kyungpook Natl Univ, Sch Dent, Dept Dent Biomat, Daegu 41940, South Korea
[3] Kyungpook Natl Univ, Sch Dent, Dept Oral Med, Daegu 41940, South Korea
[4] Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu 41940, South Korea
来源：
MOLECULAR BRAIN | 2024年 / 17卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
O-GlcNAcylation; O-GlcNAc transferase; O-GlcNAcase; Synaptic transmission; Synaptic plasticity; GLCNAC-MODIFIED PROTEINS; IDENTIFICATION; GLYCOSYLATION; LOCALIZATION; TRANSFERASE; CREB;
D O I：
10.1186/s13041-023-01072-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by two enzymes: O-GlcNAc transferase and O-GlcNAcase. In addition to roles in diabetes and cancer, recent pharmacological and genetic studies have revealed that O-GlcNAcylation is involved in neuronal function, specifically synaptic transmission. Global alteration of the O-GlcNAc level does not affect basal synaptic transmission while the effect on synaptic plasticity is unclear. Although synaptic proteins that are O-GlcNAcylated are gradually being discovered, the mechanism of how O-GlcNAcylated synaptic protein modulate synaptic transmission has only been reported on CREB, synapsin, and GluA2 subunit of AMPAR. Future research enabling the manipulation of O-GlcNAcylation in individual synaptic proteins should reveal hidden aspects of O-GlcNAcylated synaptic proteins as modulators of synaptic transmission.
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页数：5
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