Recent Insights of Metformin on Hepatocellular Carcinoma (HCC)

被引：3

作者：

Wang, Kaizhen ^{[1
]}

Zhang, Kuojun ^{[1
]}

Zhang, Xiangyu ^{[1
]}

Chen, Dong ^{[1
]}

Jiang, Sheng ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2023年 / 23卷 / 11期

基金：

中国国家自然科学基金;

关键词：

HCC; metformin; mechanism; cell cycle arrest; apoptosis; immune modulation; PANCREATIC-CANCER CELLS; INDUCED LIPID-ACCUMULATION; ACTIVATED PROTEIN-KINASE; FATTY-ACID SYNTHASE; IN-VITRO; ANTIDIABETIC DRUG; HEPG2; CELLS; KAPPA-B; MULTIDRUG-RESISTANCE; DIABETIC-PATIENTS;

D O I：

10.2174/1389557522666220623150717

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Metformin is an oral hypoglycemic drug, the first option used to treat type 2 diabetes mellitus due to its high efficacy and low cost. Recently, it has drawn attention among researchers due to its new-found antitumor effect. Growing evidence showed that metformin could inhibit cancer progression, especially in hepatocellular carcinoma, and several clinical trials are underway. However, the underlying mechanisms of the inhibition of hepatocellular carcinoma remain to be further explored and clarified. Herein, we reviewed the latest findings of how metformin acts against hepatocellular carcinoma and the proposed mechanisms. In addition, we included related preclinical trials, along with the limitations and perspectives of its treatment in hepatocellular carcinoma, providing novel ideas for research to conquer hepatocellular carcinoma.

引用

页码：1154 / 1166

页数：13

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