A systematic review and meta-analysis of radiotherapy and particle beam therapy for skull base chondrosarcoma: TRP-chondrosarcoma 2024

被引：5

作者：

Nakamura, Masatoshi ^{[1
]}

Mizumoto, Masashi ^{[1
]}

Saito, Takashi ^{[1
]}

Shimizu, Shosei ^{[2
]}

Li, Yinuo ^{[1
]}

Oshiro, Yoshiko ^{[1
,3
]}

Inaba, Masako ^{[4
]}

Hosaka, Sho ^{[4
]}

Fukushima, Hiroko ^{[5
]}

Suzuki, Ryoko ^{[5
]}

Iizumi, Takashi ^{[1
]}

Nakai, Kei ^{[1
]}

Maruo, Kazushi ^{[6
]}

Sakurai, Hideyuki ^{[1
]}

机构：

[1] Univ Tsukuba, Dept Radiat Oncol, Tsukuba, Japan

[2] Hebei Yizhou Canc Hosp, Dept Pediat, Pediat Proton Beam Therapy Ctr, Radiat Therapy Ctr, Zhuozhou, Peoples R China

[3] Tsukuba Med Ctr Hosp, Dept Radiat Oncol, Tsukuba, Japan

[4] Univ Tsukuba Hosp, Dept Pediat, Tsukuba, Japan

[5] Univ Tsukuba, Inst Med, Dept Child Hlth, Tsukuba, Japan

[6] Univ Tsukuba, Inst Med, Dept Biostat, Tsukuba, Japan

来源：

FRONTIERS IN ONCOLOGY | 2024年 / 14卷

关键词：

chondrosarcoma; skull base; proton; meta-analysis; systematic review; temporal lobe necrosis; TRP; PROTON RADIATION-THERAPY; LONG-TERM OUTCOMES; PROGNOSTIC-FACTORS; CHORDOMA; PATTERNS; NECROSIS;

D O I：

10.3389/fonc.2024.1380716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Chondrosarcoma is a rare malignant bone tumor. Particle beam therapy (PT) can concentrate doses to targets while reducing adverse events. A meta-analysis based on a literature review was performed to examine the efficacy of PT and photon radiotherapy for skull base chondrosarcoma. Methods: The meta-analysis was conducted using 21 articles published from 1990 to 2022. Results: After PT, the 3- and 5-year overall survival (OS) rates were 94.1% (95% confidence interval [CI]: 91.0-96.2%) and 93.9% (95% CI: 90.6-96.1%), respectively, and the 3- and 5-year local control rates were 95.4% (95% CI: 92.0-97.4%) and 90.1% (95% CI: 76.8-96.0%), respectively. Meta-regression analysis revealed a significant association of PT with a superior 5-year OS rate compared to three-dimensional conformal radiotherapy (p < 0.001). In the studies used in the meta-analysis, the major adverse event of grade 2 or higher was temporal lobe necrosis (incidence 1-18%, median 7%). Conclusion: PT for skull base chondrosarcoma had a good outcome and may be a valuable option among radiotherapy modalities. However, high-dose postoperative irradiation of skull base chondrosarcoma can cause adverse events such as temporal lobe necrosis.

引用

页数：7

共 37 条

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