共 57 条
Xuebijing Injection Attenuates Heat Stroke-Induced Brain Injury through Oxidative Stress Blockage and Parthanatos Modulation via PARP-1/AIF Signaling
被引:11
作者:

Wang, Lin
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机构:
Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Emergency, Guangzhou 510405, Guangdong, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Emergency, Guangzhou 510405, Guangdong, Peoples R China

Ye, Boxin
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机构:
Guangzhou Univ Chinese Med, Clin Med Sch 1, Guangzhou 510405, Guangdong, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Emergency, Guangzhou 510405, Guangdong, Peoples R China

Liu, Yongrui
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机构:
Guangzhou Univ Chinese Med, Clin Med Sch 1, Guangzhou 510405, Guangdong, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Emergency, Guangzhou 510405, Guangdong, Peoples R China

Li, Jun
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机构:
Guangzhou Univ Chinese Med, Clin Med Sch 1, Guangzhou 510405, Guangdong, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Emergency, Guangzhou 510405, Guangdong, Peoples R China

Li, Chunhe
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机构:
Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Crit Care Med, Guangzhou 510405, Guangdong, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Emergency, Guangzhou 510405, Guangdong, Peoples R China

Wen, Minyong
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h-index: 0
机构:
Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Crit Care Med, Guangzhou 510405, Guangdong, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Emergency, Guangzhou 510405, Guangdong, Peoples R China

Li, Hongbo
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h-index: 0
机构:
Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Crit Care Med, Guangzhou 510405, Guangdong, Peoples R China Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Emergency, Guangzhou 510405, Guangdong, Peoples R China
机构:
[1] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Emergency, Guangzhou 510405, Guangdong, Peoples R China
[2] Guangzhou Univ Chinese Med, Clin Med Sch 1, Guangzhou 510405, Guangdong, Peoples R China
[3] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Crit Care Med, Guangzhou 510405, Guangdong, Peoples R China
来源:
基金:
中国国家自然科学基金;
关键词:
CELL-DEATH;
DAMAGE;
MICE;
D O I:
10.1021/acsomega.3c03084
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Heat stroke (HS) is a potentially fatal acute condition caused by an interplay of complex events including inflammation, endothelial injury, and coagulation abnormalities that make its pharmacological treatment a challenging problem. The traditional Chinese medicine Xuebijing injection (XBJ) has been shown to reduce inflammatory responses and prevent organ injuries in HS-induced mice. However, the underlying mechanism of XBJ in HS-induced brain injury remains unclear. In this study, HS-induced rat models and cell models were established to elucidate the effects and underlying mechanisms of XBJ injection on HS-induced brain injury in vivo and in vitro. The results revealed that XBJ injection improved the survival outcome of HS rats and attenuated HS-induced brain injury in a concentration-dependent manner. Subsequently, the reduction in viability and proliferation of neurons induced by HS were reversed by XBJ treatment, while the HS-induced increased ROS levels and neuron death were also inhibited by XBJ injection. Mechanistically, HS activated PARP-1/AIF signaling in vitro and in vivo, inducing the translocation of AIF from the cytoplasm to the nucleus, leading to PARP-1-dependent cell death of neurons. Additionally, we compared XBJ injection effects in young and old age rats. Results showed that XBJ also provided protective effects in HS-induced brain injury in aging rats; however, the treatment efficacy of XBJ injection at the same concentration was more significant in the young age rats. In conclusion, XBJ injection attenuates HS-induced brain injury by inhibiting oxidative stress and Parthanatos via the PARP-1/AIF signaling, which might provide a novel therapeutic strategy for HS treatment.
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收藏
页码:33392 / 33402
页数:11
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