A Shear-Thinning, Self-Healing, Dual-Cross Linked Hydrogel Based on Gelatin/Vanillin/Fe3+/AGP-AgNPs: Synthesis, Antibacterial, and Wound-Healing Assessment

被引：10

作者：

Talodthaisong, Chanon ^{[1
,2
]}

Patramanon, Rina ^{[3
]}

Thammawithan, Saengrawee ^{[3
]}

Lapmanee, Sarawut ^{[4
]}

Maikaeo, Lamai ^{[5
]}

Sricharoen, Phitchan ^{[6
]}

Khongkow, Mattaka ^{[7
]}

Namdee, Katawut ^{[7
]}

Jantimaporn, Angkana ^{[7
]}

Kayunkid, Navaphun ^{[8
]}

Hutchison, James A. A. ^{[9
,10
]}

Kulchat, Sirinan ^{[1
,2
]}

机构：

[1] Khon Kaen Univ, Fac Sci, Mat Chem Res Ctr, Dept Chem, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Fac Sci, Ctr Excellence Innovat Chem, Khon Kaen 40002, Thailand

[3] Khon Kaen Univ, Fac Sci, Dept Biochem, Khon Kaen 40002, Thailand

[4] Siam Univ, Fac Med, Dept Basic Med Sci, Bangkok 10160, Thailand

[5] Thailand Inst Nucl Technol Publ Org, Nucl Technol Res & Dev Ctr, Nakhon Nayok 26120, Thailand

[6] Thonburi Univ, Fac Med, Dept Premed Sci, Bangkok 10170, Thailand

[7] Natl Sci & Technol Dev Agcy, Natl Nanotechnol Ctr, Pathum Thani 12120, Thailand

[8] King Mongkuts Inst Technol Ladkrabang, Coll Mat Innovat & Technol, Bangkok 10520, Thailand

[9] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia

[10] Univ Melbourne, Ctr Excellence Exciton Sci, Parkville, Vic 3010, Australia

来源：

MACROMOLECULAR BIOSCIENCE | 2023年 / 23卷 / 12期

基金：

澳大利亚研究理事会;

关键词：

andrographolide; antibacterial; gelatin; self-healing hydrogel; silver nanoparticles; vanillin; EPITHELIALIZATION; VANILLIN; CHITOSAN; DESIGN; REPAIR;

D O I：

10.1002/mabi.202300250

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A shear-thinning and self-healing hydrogel based on a gelatin biopolymer is synthesized using vanillin and Fe3+ as dual crosslinking agents. Rheological studies indicate the formation of a strong gel found to be injectable and exhibit rapid self-healing (within 10 min). The hydrogels also exhibited a high degree of swelling, suggesting potential as wound dressings since the absorption of large amounts of wound exudate, and optimum moisture levels, lead to accelerated wound healing. Andrographolide, an anti-inflammatory natural product is used to fabricate silver nanoparticles, which are characterized and composited with the fabricated hydrogels to imbue them with anti-microbial activity. The nanoparticle/hydrogel composites exhibit activity against Escherichia coli, Staphylococcus aureus, and Burkholderia pseudomallei, the pathogen that causes melioidosis, a serious but neglected disease affecting southeast Asia and northern Australia. Finally, the nanoparticle/hydrogel composites are shown to enhance wound closure in animal models compared to the hydrogel alone, confirming that these hydrogel composites hold great potential in the biomedical field.

引用

页数：15

共 58 条

[1] Self-Healing Materials Systems: Overview of Major Approaches and Recent Developed Technologies [J].