Calcium promotes vascular smooth muscle cell phenotypic switching in Marfan syndrome

被引：1

作者：

Yang, Yunxiao ^{[1
]}

Xie, Enzehua ^{[2
]}

Liu, Yuhua ^{[1
]}

Peng, Zhan ^{[1
]}

Yu, Cuntao ^{[2
]}

Hua, Kun ^{[1
]}

Yang, Xiubin ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiovasc Surg, Beijing 100029, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, Dept Cardiovasc Surg, Beijing 100047, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2023年 / 665卷

关键词：

Marfan syndrome; Vascular smooth muscle cell; Phenotypic switching; Calcium; AORTIC-ANEURYSM; PROLIFERATION; SERCA;

D O I：

10.1016/j.bbrc.2023.05.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibrillin 1 (Fbn1) mutations cause Marfan syndrome (MFS), with aortic root dilatation, dissection, and rupture. Few studies reported the blood calcium and lipid profile of MFS, and the effect of vascular smooth muscle cell (VSMC) phenotypic switching on MFS aortic aneurysm is unclear. Here, we aimed to investigate the role of calcium-related VSMC phenotypic switching in MFS. We retrospectively collected MFS patients' clinical data, performed bioinformatics analysis to screen the enriched biological process in MFS patients and mice, and detected markers of VSMC phenotypic switching on Fbn1C1039G/ thorn mice and primary aortic vascular smooth muscle cells. We found that patients with MFS have elevated blood calcium levels and dyslipidemia. Furthermore, the calcium concentration levels were increased with age in MFS mice, accompanied by the promoted VSMC phenotypic switching, and SERCA2 contributed to maintaining the contractile phenotype of VSMCs. This study provides the first evidence that the increased calcium is associated with the promoted VSMC phenotype switching in MFS. SERCA may become a novel therapeutic target for suppressing aneurysm progression in MFS. (c) 2023 Elsevier Inc. All rights reserved.

引用

页码：124 / 132

页数：9

共 36 条

[11] Importance of Altered Levels of SERCA, IP3R, and RyR in Vascular Smooth Muscle Cell[J]. Johny, Jaijus Pallippadan;Plank, Michael J.;David, Tim. BIOPHYSICAL JOURNAL, 2017(02)
[12] Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders[J]. Kang, Soojeong;Dahl, Russell;Hsieh, Wilson;Shin, Andrew;Zsebo, Krisztina M.;Buettner, Christoph;Hajjar, Roger J.;Lebeche, Djamel. JOURNAL OF BIOLOGICAL CHEMISTRY, 2016(10)
[13] Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3[J]. Li, Dong-Jie;Tong, Jie;Zeng, Fei-Yan;Guo, Mengqi;Li, Yong-Hua;Wang, Hongbo;Wang, Pei. BRITISH JOURNAL OF PHARMACOLOGY, 2019(22)
[14] Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload[J]. Li, Siwen;Ma, Yu;Ye, Shuzi;Tang, Sixuan;Liang, Ningjuan;Liang, Yuehui;Xiao, Fang. JOURNAL OF HAZARDOUS MATERIALS, 2021
[15] Sarco/endoplasmic reticulum Ca2+-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat[J]. Lipskaia, L;del Monte, F;Capiod, T;Yacoubi, S;Hadri, L;Hours, M;Hajjar, RJ;Lompré, AM. CIRCULATION RESEARCH, 2005(05)
[16] Inactivation of Cys674 in SERCA2 increases BP by inducing endoplasmic reticulum stress and soluble epoxide hydrolase[J]. Liu, Gang;Wu, Fuhua;Jiang, Xiaoli;Que, Yumei;Qin, Zhexue;Hu, Pingping;Lee, Kin Sing Stephen;Yang, Jian;Zeng, Chunyu;Hammock, Bruce D.;Tong, Xiaoyong. BRITISH JOURNAL OF PHARMACOLOGY, 2020(08)
[17] Intracellular Ca2+ Signalling and Phenotype of Vascular Smooth Muscle Cells[J]. Matchkov, Vladimir V.;Kudryavtseva, Olga;Aalkjaer, Christian. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2012(01)
[18] Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates[J]. Newby, AC. CARDIOVASCULAR RESEARCH, 2006(03)
[19] Extracellular Tuning of Mitochondrial Respiration Leads to Aortic Aneurysm[J]. Oller, Jorge;Gabande-Rodriguez, Enrique;Ruiz-Rodriguez, Maria Jesus;Desdin-Mico, Gabriela;Aranda, Juan Francisco;Rodrigues-Diez, Raquel;Ballesteros-Martinez, Constanza;Blanco, Eva Maria;Roldan-Montero, Raquel;Acuna, Pedro;Forteza Gil, Alberto;Martin-Lopez, Carlos E.;Nistal, J. Francisco;Lino Cardenas, Christian L.;Lindsay, Mark Evan;Martin-Ventura, Jose Luis;Briones, Ana M.;Miguel Redondo, Juan;Mittelbrunn, Maria. CIRCULATION, 2021(21)
[20] Pedroza A.J., ARTERIOSCL THROM VAS

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