Long-term efficacy and safety of adjunctive perampanel in pediatric patients aged 4-19 years with epilepsy: a real-world study

被引:4
作者
Youn, Song Ee [1 ,2 ]
Kang, Hoon-Chul [1 ]
Lee, Joon Soo [1 ]
Kim, Heung Dong [1 ]
Kim, Se Hee [1 ]
机构
[1] Yonsei Univ, Coll Med, Severance Childrens Hosp, Div Pediat Neurol,Dept Pediat, 50-1 Yonsei Ro, Seoul 03722, South Korea
[2] Hallym Univ, Kangdong Sacred Heart Hosp, Coll Med, Dept Pediat, 150 Seongan Ro, Seoul 05355, South Korea
关键词
TOLERABILITY;
D O I
10.1038/s41598-023-40594-8
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study determined the 24-month outcomes of perampanel treatment in children and adolescents with epilepsy. The percentage of >= 50% responders was 47.3% (139/294) at 12 months and 49.0% (144/294) at 24 months. A 100% reduction in seizures for more than 12 months was observed in 12.2% (36/294). Discontinuation occurred in 39.8% (117/294). The most common reason for discontinuation was adverse events (29.1%, 34/117). Baseline seizure frequency was higher in children aged < 12 years than in patients aged >= 12 years; however, the percentage of seizure reduction and >= 50% responders did not significantly differ between the two groups. The rate of early discontinuation was higher (p < 0.001) and the duration of perampanel treatment was shorter in children aged < 12 years (p = 0.001). Most children aged < 12 years discontinued PER due to inadequate effectiveness, while adverse event was the most common reason in patients aged >= 12 years (p = 0.045). Only slow titration was significantly associated with >= 50% of responders. In conclusion, this study showed that perampanel can be utilized effectively and safely for a prolonged period in pediatric patients aged 4 to < 12 years, as well as in patients aged 12 years and older.
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页数:8
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