Protective effects of edible insect protein extracts from Protaetia brevitarsis against H2O2-induced oxidative stress in mouse C2C12 myoblast cells

被引：13
|
作者：
Lee, Jae Hoon [1 ]
Kim, Tae-Kyung [1 ]
Kang, Min-Cheol [1 ]
Kim, Bum-Keun [1 ]
Choi, Yun-Sang [1 ]
机构：
[1] Korea Food Res Inst, Res Grp Food Proc, Wonju 55365, South Korea
来源：
FOOD BIOSCIENCE | 2023年 / 52卷
关键词：
Edible insect protein extract; Protaetia brevitarsis; Antioxidant; Anti-Apoptosis; ANTIOXIDANT ACTIVITY; ROS GENERATION; WHEY-PROTEIN; PEPTIDES; APOPTOSIS; ANTICANCER; LARVAE; BCL-2;
D O I：
10.1016/j.fbio.2023.102396
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Edible insects have been attracting significant attention not only for their nutritional superiority but also for their excellent bio-functional activity. In this study, the apoptotic protective effects of water-soluble protein (WPB) and salt-soluble protein (SPB) extracts derived from Protaetia brevitarsis against hydrogen peroxide (H2O2)-induced oxidative stress in C2C12 cells were investigated. WPB and SPB were confirmed to exhibit radical scavenging and ferric-ion reducing activities. In addition, WPB and SPB treatments effectively restored the decreased cell viability of the C2C12 cells induced by H2O2 treatment, and showcased protective effects against apoptosis and mitochondrial dysfunction by regulating the expressions of pro-and anti-apoptotic proteins. Therefore, our data indicated that protein extracts from Protaetia brevitarsis could be beneficial for the prevention and treatment of diseases associated with apoptosis induced by oxidative stress.
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页数：9
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