Synthesis, characterization and anticancer screening of novel phenylbenzylidene thiosemicarbazone derivatives

被引：4
作者：
Anisree, S. [1 ]
Shanmugavelan, P. [1 ]
Vijayalakshmi, P. [1 ]
Kishore, Ram [2 ]
Srivastava, Nitin [2 ,3 ]
机构：
[1] Tamilnadu Open Univ, Dept Chem, Chennai, Tamil Nadu, India
[2] Amity Univ, Dept Chem, Lucknow Campus, Lucknow, India
[3] Amity Univ Uttar Pradesh, Dept Chem, Lucknow Campus, Lucknow, India
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2024年 / 199卷 / 04期
关键词：
Thiosemicarbazones; Triton-B; Fe-59; mobilization; uptake; ascorbate oxidation; SELECTIVE ANTINEOPLASTIC ACTIVITY; IRON CHELATORS; PALLADIUM(II) COMPLEXES; BIOLOGICAL EVALUATION; ANTIMALARIAL ACTIVITY; METAL-COMPLEXES; POTENT; DESIGN; ANTIBACTERIAL; SEMICARBAZONE;
D O I：
10.1080/10426507.2024.2330935
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Ten derivatives of phenylbenzylidene thiosemicarbazones (1-10) were synthesized by multicomponent reaction between hydrazine hydrate, isothiocyanate and substituted aldehydes in the presence of the phase transfer reagent Triton-B and subsequently heating the mixture. The synthesized compounds 1, 2, 5, 8 demonstrated to act as highly potent anticancer agents. They showed anticancer activity by mobilizing cellular Fe-59, inhibiting cellular uptake of 59Fe from Fe-59(2)-Tf, and mediating the ascorbate oxidation. Further, the structure activity relationship revealed that the donor atom and its stabilization resulted in better anticancer activity. The softness of the chelating donor atoms N and S yielded redox active iron complexes, which easily mediated ascorbate oxidation. This study identified the selective and potential chelators, which may act as anticancer agents and require further in vivo screening in future.
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页码：267 / 276
页数：10
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