Synthesis of Diverse 4-Pyrrolin-2-ones by Electrochemically Induced Dehydrogenative Regioselective Cyclization of 3-Aza-1,5-dienes and 1,3-Dicarbonyl Compounds

A practical and mild electrochemical dehydrogenative regioselective cyclization method has been established for the synthesis of 4-pyrrolin-2-ones using 3-aza-1,5-dienes and 1,3-dicarbonyl compounds as substrates. This protocol is catalyst-free, metal-free, and does not require oxidizing agents. It exhibits wide substrate compatibility and can be easily scaled up to the gram scale. A catalyst-free, metal-free, and oxidizing-agent-free electrochemical dehydrogenative regioselective cyclization for the synthesis of 4-pyrrolin-2-ones from 3-aza-1,5-dienes and 1,3-dicarbonyl compounds is presented. This method offers a wide range of substrate compatibility and can be readily scaled up to the gram scale. image