Crosslinked chitosan/γ-polyglutamic acid sponge carrying berberine for hemostasis and wound healing

被引：11

作者：

Zou, Qinglin ^{[1
]}

Wang, Xue ^{[1
]}

Li, Siqiang ^{[2
]}

Zhang, Xuanming ^{[1
]}

Zhang, Shanshan ^{[1
]}

Li, Peihai ^{[1
]}

Li, Xiaobin ^{[1
]}

Lin, Houwen ^{[3
]}

Liu, Kechun ^{[1
]}

Wang, Rongchun ^{[1
]}

Wang, Lizhen ^{[1
]}

机构：

[1] Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Jinan 250103, Peoples R China

[2] HuangHuai Univ, Sch Biol & Food Proc Engn, Zhumadian 463000, Peoples R China

[3] Shanghai Jiao Tong Univ, Res Ctr Marine Drugs, State Key Lab Oncogenes & Related Genes, Shanghai 200127, Peoples R China

来源：

MATERIALS CHEMISTRY AND PHYSICS | 2024年 / 311卷

关键词：

Chitosan; gamma-Polyglutamic acid; Hemostatic sponge; Wound healing; Berberine; HYDROGEL; ANTIBACTERIAL; REPAIR;

D O I：

10.1016/j.matchemphys.2023.128527

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Wound healing material with good hemostatic ability is urgently needed in clinical. Herein, we prepared a crosslinked chitosan/gamma-polyglutamic acid sponge loading berberine (CPG-B3) for hemostasis and wound healing. The CPG-B3 sponge could absorb a large number of water in the bleeding point, which led to the accumulation of various blood coagulation factors and quick hemostasis. The presence of berberine enhanced the antibacterial activity of CPG-B3. In vitro biological investigations indicated that CPG-B3 showed low hemolysis ratio, the proliferation and migration of L929 cells incubated with CPG-B3 were not affected. In vivo studies revealed that CPG-B3 showed good hemostatic ability in a liver rupture bleeding model, and could accelerate the bacterial-infected wound healing process. Overall, the sponge shows great potential as hemostatic and wound healing material.

引用

页数：10

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