Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening

被引：26

作者：

Daylan, Ayse Ece Cali ^{[1
]}

Miao, Emily ^{[2
]}

Tang, Kevin ^{[2
]}

Chiu, Grace ^{[3
]}

Cheng, Haiying ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Oncol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Med, Montefiore Med Ctr, Bronx, NY USA

[3] Scarsdale High Sch, Scarsdale, NY USA

来源：

LUNG | 2023年 / 201卷 / 06期

关键词：

Lung cancer; Never smoker; Genomic landscape; Screening; NSCLC; SCLC; ONCOGENIC DRIVER MUTATIONS; FACTOR RECEPTOR MUTATIONS; CLINICAL CHARACTERISTICS; SUSCEPTIBILITY LOCUS; NONSMOKING WOMEN; PASSIVE SMOKING; LARGE COHORT; RISK; SURVIVAL; EXPOSURE;

D O I：

10.1007/s00408-023-00661-3

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Lung cancer in never smokers (LCINS) represents a growing and distinct entity within the broader landscape of lung malignancies. This review provides a comprehensive overview of LCINS, encompassing its epidemiologic trends, risk factors, distinct genomic alterations, clinical outcomes and the ongoing initiative aimed at formulating screening guidelines tailored to this unique population. As LCINS continues to gain prominence, understanding its intricate genomic landscape has become pivotal for tailoring effective therapeutic strategies. Moreover, LCINS does not meet the criteria for lung cancer screening as per the current guidelines. Hence, there is an urgent need to explore its heterogeneity in order to devise optimal screening guidelines conducive to early-stage detection. This review underscores the vital importance of detailed research to elucidate the multifaceted nature of LCINS, with the potential to shape future clinical management and screening recommendations for this unique and growing patient cohort.

引用

页码：635 / 639

页数：5

共 94 条

[1] PREEXISTING LUNG-DISEASE AND LUNG-CANCER AMONG NONSMOKING WOMEN [J].

ALAVANJA, MCR ;

BROWNSON, RC ;

BOICE, JD ;

HOCK, E .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1992, 136 (06) :623-632

[2] A Susceptibility Locus on Chromosome 6q Greatly Increases Lung Cancer Risk among Light and Never Smokers [J].

Amos, Christopher I. ;

Pinney, Susan M. ;

Li, Yafang ;

Kupert, Elena ;

Lee, Juwon ;

de Andrade, Mariza A. ;

Yang, Ping ;

Schwartz, Ann G. ;

Fain, Pam R. ;

Gazdar, Adi ;

Minna, John ;

Wiest, Jonathan S. ;

Zeng, Dong ;

Rothschild, Henry ;

Mandal, Diptasri ;

You, Ming ;

Coons, Teresa ;

Gaba, Colette ;

Bailey-Wilson, Joan E. ;

Anderson, Marshall W. .

CANCER RESEARCH, 2010, 70 (06) :2359-2367

[3] Prevalence, Clinicopathologic Associations, and Molecular Spectrum of ERBB2 (HER2) Tyrosine Kinase Mutations in Lung Adenocarcinomas [J].

Arcila, Maria E. ;

Chaft, Jamie E. ;

Nafa, Khedoudja ;

Roy-Chowdhuri, Sinchita ;

Lau, Christopher ;

Zaidinski, Michael ;

Paik, Paul K. ;

Zakowski, Maureen F. ;

Kris, Mark G. ;

Ladanyi, Marc .

CLINICAL CANCER RESEARCH, 2012, 18 (18) :4910-4918

[4] Second hand smoke, age of exposure and tung cancer risk [J].

Asomaning, Kofi ;

Miller, David P. ;

Liu, Geoffrey ;

Wain, John C. ;

Lynch, Thomas J. ;

Su, Li ;

Christiani, David C. .

LUNG CANCER, 2008, 61 (01) :13-20

[5] A major lung cancer susceptibility locus maps to chromosome 6q23-25 [J].

Bailey-Wilson, JE ;

Amos, CI ;

Pinney, SM ;

Petersen, GM ;

de Andrade, M ;

Wiest, JS ;

Fain, P ;

Schwartz, AG ;

You, M ;

Franklin, W ;

Klein, C ;

Gazdar, A ;

Rothschild, H ;

Mandal, D ;

Coons, T ;

Slusser, J ;

Lee, J ;

Gaba, C ;

Kupert, E ;

Perez, A ;

Zhou, X ;

Zeng, D ;

Liu, Q ;

Zhang, Q ;

Seminara, D ;

Minna, J ;

Anderson, MW .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (03) :460-474

[6] ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers [J].

Bergethon, Kristin ;

Shaw, Alice T. ;

Ou, Sai-Hong Ignatius ;

Katayama, Ryohei ;

Lovly, Christine M. ;

McDonald, Nerina T. ;

Massion, Pierre P. ;

Siwak-Tapp, Christina ;

Gonzalez, Adriana ;

Fang, Rong ;

Mark, Eugene J. ;

Batten, Julie M. ;

Chen, Haiquan ;

Wilner, Keith D. ;

Kwak, Eunice L. ;

Clark, Jeffrey W. ;

Carbone, David P. ;

Ji, Hongbin ;

Engelman, Jeffrey A. ;

Mino-Kenudson, Mari ;

Pao, William ;

Iafrate, A. John .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (08) :863-870

[7] The genomic landscape of nonsmall cell lung carcinoma in never smokers [J].

Boeckx, Bram ;

Shahi, Rajendra B. ;

Smeets, Dominiek ;

De Brakeleer, Sylvia ;

Decoster, Lore ;

Van Brussel, Thomas ;

Galdermans, Daniella ;

Vercauter, Piet ;

Decoster, Lynn ;

Alexander, Patrick ;

Berchem, Guy ;

Ocak, Sebahat ;

Vuylsteke, Peter ;

Deschepper, Koen ;

Lambrechts, Marc ;

Cappoen, Nadia ;

Teugels, Erik ;

Lambrechts, Diether ;

De Greve, Jacques .

INTERNATIONAL JOURNAL OF CANCER, 2020, 146 (11) :3207-3218

[8] Incidence of lung cancer in a large cohort of non-smoking men from Sweden [J].

Boffetta, P ;

Järvholm, B ;

Brennan, P ;

Nyrén, O .

INTERNATIONAL JOURNAL OF CANCER, 2001, 94 (04) :591-593

[9] Lung cancer risk in never-smokers: a population-based case-control study of epidemiologic risk factors [J].

Brenner, Darren R. ;

Hung, Rayjean J. ;

Tsao, Ming-Sound ;

Shepherd, Frances A. ;

Johnston, Michael R. ;

Narod, Steven ;

Rubenstein, Warren ;

McLaughlin, John R. .

BMC CANCER, 2010, 10

[10] Idiopathic Pulmonary Fibrosis and Lung Cancer A Systematic Review and Meta-analysis [J].

Brown, Stacey-Ann Whittaker ;

Dobelle, Molly ;

Padilla, Maria ;

Agovino, Mariangela ;

Wisnivesky, Juan P. ;

Hashim, Dana ;

Boffetta, Paolo .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2019, 16 (08) :1041-1051

← 1 2 3 4 5 6 7 8 9 10 →