cGAS-STING, an important signaling pathway in diseases and their therapy

被引：30

作者：

Li, Qijie ^{[1
]}

Wu, Ping ^{[2
]}

Du, Qiujing ^{[1
]}

Hanif, Ullah ^{[1
]}

Hu, Hongbo ^{[3
]}

Li, Ka ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Sichuan Prov Med & Engn Interdisciplinary Res Ctr, West China Sch Nursing,Nursing Key Lab Sichuan Pro, Chengdu 610041, Sichuan, Peoples R China

[2] China Natl Nucl Corp Hosp 416, Affiliated Hosp 2, Chengdu Med Coll, Dept Occupat Dis, Chengdu, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Ctr Immunol & Hematol, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

来源：

MEDCOMM | 2024年 / 5卷 / 04期

关键词：

agonist; cancer immunotherapy; cGAS-STING; inflammatory disease; inhibitor; signal transduction regulation; triggered DNA; CYCLIC GMP-AMP; DNA SENSOR CGAS; ENDOPLASMIC-RETICULUM STRESS; AICARDI-GOUTIERES-SYNDROME; INNATE ANTIVIRAL RESPONSE; I INTERFERON INDUCTION; DOUBLE-STRANDED DNA; MITOCHONDRIAL-DNA; IFN-BETA; TUMOR MICROENVIRONMENT;

D O I：

10.1002/mco2.511

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Since cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great progress has been made to elucidate the origin, function, and regulating mechanism of cGAS-STING signaling pathway in the past decade. Meanwhile, the triggering and transduction mechanisms have been continuously illuminated. cGAS-STING plays a key role in human diseases, particularly DNA-triggered inflammatory diseases, making it a potentially effective therapeutic target for inflammation-related diseases. Here, we aim to summarize the ancient origin of the cGAS-STING defense mechanism, as well as the triggers, transduction, and regulating mechanisms of the cGAS-STING. We will also focus on the important roles of cGAS-STING signal under pathological conditions, such as infections, cancers, autoimmune diseases, neurological diseases, and visceral inflammations, and review the progress in drug development targeting cGAS-STING signaling pathway. The main directions and potential obstacles in the regulating mechanism research and therapeutic drug development of the cGAS-STING signaling pathway for inflammatory diseases and cancers will be discussed. These research advancements expand our understanding of cGAS-STING, provide a theoretical basis for further exploration of the roles of cGAS-STING in diseases, and open up new strategies for targeting cGAS-STING as a promising therapeutic intervention in multiple diseases. cGAS-STING signaling pathway was discovered in 2013. With so many years of in-depth research on cGAS-STING, people have realized that cGAS-STING plays a key role in human diseases, particularly DNA-triggered inflammatory diseases and cancers. This review summarize the ancient origin, triggers, transduction, and regulating mechanisms of the cGAS-STING. The main directions and potential obstacles in the regulating mechanism research and therapeutic drug development of the cGAS-STING signaling pathway for inflammatory diseases and cancers will be discussed. image

引用

页数：51