The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus

被引：9
|
作者：
Valentini, Alessia [1 ]
Cardillo, Carmine [2 ,3 ]
Della Morte, David [1 ]
Tesauro, Manfredi [1 ]
机构：
[1] Tor Vergata Univ, Dept Syst Med, I-00133 Rome, Italy
[2] Policlin A Gemelli IRCCS, Dept Aging, I-00168 Rome, Italy
[3] Catholic Univ, Dept Translat Med & Surg, I-00168 Rome, Italy
来源：
BIOMEDICINES | 2023年 / 11卷 / 11期
基金：
英国科研创新办公室;
关键词：
non-communicable diseases (NCDs); perivascular adipose tissue (PVAT); endothelial dysfunction (ED); cardiovascular diseases (CVDs); insulin resistance (IR); type 2 diabetes mellitus (T2DM); NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; VASCULAR FUNCTION; OXIDATIVE STRESS; GLUCOSE-UPTAKE; DEPENDENT VASOCONSTRICTION; SMALL ARTERIES; OBESITY; MUSCLE; FAT;
D O I：
10.3390/biomedicines11113006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable diseases (NCDs) representing the leading cause of death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a central role in the pathogenesis of these chronic diseases. Although it is well known that systemic chronic inflammation and oxidative stress are primarily involved in the development of ED, recent studies have shown that perivascular adipose tissue (PVAT) is implicated in its pathogenesis, also contributing to the progression of atherosclerosis and to insulin resistance (IR). In this review, we describe the relationship between PVAT and ED, and we also analyse the role of PVAT in the pathogenesis of CVDs and T2DM, further assessing its potential therapeutic target with the aim of restoring normal ED and reducing global cardiovascular risk.
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页数：16
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