Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment

被引：55

作者：

Clemente-Suarez, Vicente Javier ^{[1
]}

Martin-Rodriguez, Alexandra ^{[1
]}

Yanez-Sepulveda, Rodrigo ^{[2
]}

Tornero-Aguilera, Jose Francisco ^{[1
]}

机构：

[1] Univ Europea Madrid, Fac Sports Sci, Tajo St S-N, Madrid 28670, Spain

[2] Univ Andres Bello, Fac Educ & Social Sci, Vina Del Mar 2520000, Chile

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 10期

关键词：

mitochondrial transfer; disease diagnosis; disease treatment; cell death; neurodegenerative diseases; metabolic disorders; cancer; MESENCHYMAL STROMAL CELLS; PLURIPOTENT STEM-CELLS; CANCER DRUG-RESISTANCE; OXIDATIVE STRESS; EXOGENOUS MITOCHONDRIA; DNA HAPLOTYPES; FATTY LIVER; TRANSPLANTATION; DYSFUNCTION; OBESITY;

D O I：

10.3390/ijms24108848

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of mitochondria from one cell to another, has recently emerged as a potential therapeutic approach for restoring mitochondrial function in diseased cells. In this review, we summarize the current understanding of mitochondrial transfer, including its mechanisms, potential therapeutic applications, and impact on cell death pathways. We also discuss the future directions and challenges in the field of mitochondrial transfer as a novel therapeutic approach in disease diagnosis and treatment.

引用

页数：33

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