Occurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis

被引:5
作者
Roy-Vallejo, Emilia [1 ,2 ]
De Cordoba-Onate, Sara Fernandez [3 ]
Delgado-Wicke, Pablo [4 ]
Triguero-Martinez, Ana [2 ,3 ]
Montes, Nuria [2 ,3 ]
Carracedo-Rodriguez, Rosa [4 ]
Zurita-Cruz, Nelly [5 ]
Marcos-Jimenez, Ana [2 ,6 ]
Lamana, Amalia [7 ]
Galvan-Roman, Jose Maria [1 ,2 ]
Villapalos Garcia, Gonzalo [2 ,8 ]
Zubiaur, Pablo [2 ,8 ]
Ciudad, Marianela [1 ]
Rabes, Laura [1 ]
Sanz, Marta [1 ]
Rodriguez, Carlos [1 ]
Villa, Almudena [1 ]
Rodriguez, Jesus alvarez [1 ]
Marcos, Celeste [9 ]
Hernando, Julia [10 ]
Diaz-Fernandez, Paula [2 ,6 ]
Abad, Francisco [2 ,8 ,11 ]
de los Santos, Ignacio [1 ,2 ,12 ]
Serrano, Diego A. Rodriguez [13 ]
Garcia-Vicuna, Rosario [2 ,3 ]
Fernandez, Carmen Suarez [1 ,2 ,14 ]
P. Gomariz, Rosa [7 ]
Munoz-Calleja, Cecilia [2 ,6 ,14 ]
Fernandez-Ruiz, Elena [2 ,4 ,14 ]
Gonzalez-Alvaro, Isidoro [2 ,3 ]
Cardenoso, Laura
PREDINMUN COVID Grp
机构
[1] Hosp Univ La Princesa, Internal Med Dept, Madrid, Spain
[2] Inst Invest Sanitaria Princesa IIS IP, Madrid, Spain
[3] Hosp Univ Princesa, Haematol Dept, Madrid, Spain
[4] Hosp Univ La Princesa, Mol Biol Unit, Madrid, Spain
[5] Hosp Univ La Princesa, Microbiol Dept, Madrid, Spain
[6] Hosp Univ La Princesa, Immunol Dept, Madrid, Spain
[7] Univ Complutense, Fac Biol, Cell Biol Dept, Madrid, Spain
[8] Univ Autonoma Madrid UAM, Hosp Univ La Princesa, Clin Pharmacol Dept, Inst Teofilo Hernando, Madrid, Spain
[9] Hosp Univ La Princesa, Pneumol Dept, Madrid, Spain
[10] Hosp Univ La Princesa, Anesthesiol Dept, Madrid, Spain
[11] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain
[12] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Infecciosas CIB, Madrid, Spain
[13] Hosp Univ La Princesa, Intens Care Unit, Madrid, Spain
[14] Univ Autonoma Madrid UAM, Madrid, Spain
关键词
SARS-CoV-2; viremia; COVID-19; single nucleotide polymorphism (SNPs); genetic variants; GENOME-WIDE ASSOCIATION; HEME OXYGENASE-1 GENE; PROMOTER VARIANT; SUSCEPTIBILITY; AUTOIMMUNE; DISEASE;
D O I
10.3389/fmed.2023.1215246
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction SARS-CoV-2 viral load has been related to COVID-19 severity. The main aim of this study was to evaluate the relationship between SARS-CoV-2 viremia and SNPs in genes previously studied by our group as predictors of COVID-19 severity.Materials and methods Retrospective observational study including 340 patients hospitalized for COVID-19 in the University Hospital La Princesa between March 2020 and December 2021, with at least one viremia determination. Positive viremia was considered when viral load was above the quantifiable threshold (20 copies/ml). A total of 38 SNPs were genotyped. To study their association with viremia a multivariate logistic regression was performed.Results The mean age of the studied population was 64.5 years (SD 16.6), 60.9% patients were male and 79.4% white non-Hispanic. Only 126 patients (37.1%) had at least one positive viremia. After adjustment by confounders, the presence of the minor alleles of rs2071746 (HMOX1; T/T genotype OR 9.9 p < 0.0001), rs78958998 (probably associated with SERPING1 expression; A/T genotype OR 2.3, p = 0.04 and T/T genotype OR 12.9, p < 0.0001), and rs713400 (eQTL for TMPRSS2; C/T + T/T genotype OR 1.86, p = 0.10) were associated with higher risk of viremia, whereas the minor alleles of rs11052877 (CD69; A/G genotype OR 0.5, p = 0.04 and G/G genotype OR 0.3, p = 0.01), rs2660 (OAS1; A/G genotype OR 0.6, p = 0.08), rs896 (VIPR1; T/T genotype OR 0.4, p = 0.02) and rs33980500 (TRAF3IP2; C/T + T/T genotype OR 0.3, p = 0.01) were associated with lower risk of viremia.Conclusion Genetic variants in HMOX1 (rs2071746), SERPING1 (rs78958998), TMPRSS2 (rs713400), CD69 (rs11052877), TRAF3IP2 (rs33980500), OAS1 (rs2660) and VIPR1 (rs896) could explain heterogeneity in SARS-CoV-2 viremia in our population.
引用
收藏
页数:10
相关论文
共 64 条
[1]   Complement Evasion Strategies of Viruses: An Overview [J].
Agrawal, Palak ;
Nawadkar, Renuka ;
Ojha, Hina ;
Kumar, Jitendra ;
Sahu, Arvind .
FRONTIERS IN MICROBIOLOGY, 2017, 8
[2]   Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity [J].
Anastassopoulou, Cleo ;
Gkizarioti, Zoi ;
Patrinos, George P. ;
Tsakris, Athanasios .
HUMAN GENOMICS, 2020, 14 (01)
[3]   Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries [J].
Banday, A. Rouf ;
Stanifer, Megan L. ;
Florez-Vargas, Oscar ;
Onabajo, Olusegun O. ;
Papenberg, Brenen W. ;
Zahoor, Muhammad A. ;
Mirabello, Lisa ;
Ring, Timothy J. ;
Lee, Chia-Han ;
Albert, Paul S. ;
Andreakos, Evangelos ;
Arons, Evgeny ;
Barsh, Greg ;
Biesecker, Leslie G. ;
Boyle, David L. ;
Brahier, Mark S. ;
Burnett-Hartman, Andrea ;
Carrington, Mary ;
Chang, Euijin ;
Choe, Pyoeng Gyun ;
Chisholm, Rex L. ;
Colli, Leandro M. ;
Dalgard, Clifton L. ;
Dude, Carolynn M. ;
Edberg, Jeff ;
Erdmann, Nathan ;
Feigelson, Heather S. ;
Fonseca, Benedito A. ;
Firestein, Gary S. ;
Gehring, Adam J. ;
Guo, Cuncai ;
Ho, Michelle ;
Holland, Steven ;
Hutchinson, Amy A. ;
Im, Hogune ;
Irby, Les'Shon ;
Ison, Michael G. ;
Joseph, Naima T. ;
Kim, Hong Bin ;
Kreitman, Robert J. ;
Korf, Bruce R. ;
Lipkin, Steven M. ;
Mahgoub, Siham M. ;
Mohammed, Iman ;
Paschoalini, Guilherme L. ;
Pacheco, Jennifer A. ;
Peluso, Michael J. ;
Rader, Daniel J. ;
Redden, David T. ;
Ritchie, Marylyn D. .
NATURE GENETICS, 2022, 54 (08) :1103-+
[4]   The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19) [J].
Batra, Neelu ;
De Souza, Cristabelle ;
Batra, Jyoti ;
Raetz, Alan G. ;
Yu, Ai-Ming .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (17) :1-16
[5]   Variation in antiviral 2′,5′-oligoadenylate synthetase (2′5′AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene [J].
Bonnevie-Nielsen, V ;
Field, LL ;
Lu, S ;
Zheng, DJ ;
Li, M ;
Martensen, PM ;
Nielsen, TB ;
Beck-Nielsen, H ;
Lau, YL ;
Pociot, F .
AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (04) :623-633
[6]   Host Polymorphisms May Impact SARS-CoV-2 Infectivity [J].
Brest, Patrick ;
Refae, Sadal ;
Mograbi, Baharia ;
Hofman, Paul ;
Milano, Gerard .
TRENDS IN GENETICS, 2020, 36 (11) :813-815
[7]   Relevant SARS-CoV-2 viremia is associated with COVID-19 severity: Prospective cohort study and validation cohort [J].
Cardenoso Domingo, Laura ;
Roy Vallejo, Emilia ;
Zurita Cruz, Nelly D. ;
Chicot Llano, Marta ;
Avalos Perez-Urria, Elena ;
Barrios, Ana ;
Hernando Santos, Julia ;
Ortiz, Javier ;
Rodriguez Garcia, Sebastian C. ;
Martin Ramirez, Alexandra ;
Ciudad Sanudo, Marianela ;
Marcos, Celeste ;
Garcia Castillo, Elena ;
Fontan Garcia-Rodrigo, Leticia ;
Gonzalez, Begona ;
Mendez, Rosa ;
Iturrate, Isabel ;
Sanz Garcia, Ancor ;
Villa, Almudena ;
Sanchez Azofra, Ana ;
Quicios, Begona ;
Arribas, David ;
Alvarez Rodriguez, Jesus ;
Patino, Pablo ;
Trigueros, Marina ;
Uriarte, Miren ;
Triguero Martinez, Ana ;
Arevalo, Cristina ;
Galvan Roman, Jose M. ;
Garcia-Vicuna, Rosario ;
Ancochea, Julio ;
Soriano, Joan B. ;
Canabal, Alfonso ;
Munoz Calleja, Cecilia ;
De la Camara, Rafael ;
Suarez Fernandez, Carmen ;
Gonzalez Alvaro, Isidoro ;
Rodriguez-Serrano, Diego A. .
JOURNAL OF MEDICAL VIROLOGY, 2022, 94 (11) :5260-5270
[8]   Association between heme oxygenase one and sepsis development in patients with moderate-to-critical COVID-19: a single-center, retrospective observational study [J].
Chen, Hsin-Yi ;
Tzeng, I-Shiang ;
Tsai, Kuo-Wang ;
Wu, Yao-Kuang ;
Cheng, Ching-Feng ;
Lu, Kuo-Cheng ;
Chung, Hsueh-Wen ;
Chao, You-Chen ;
Su, Wen-Lin .
EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2022, 27 (01)
[9]   Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases [J].
Choi, Un Yung ;
Kang, Ji-Seon ;
Hwang, Yune Sahng ;
Kim, Young-Joon .
EXPERIMENTAL AND MOLECULAR MEDICINE, 2015, 47 :e144-e144
[10]   CD69 Limits the Severity of Cardiomyopathy After Autoimmune Myocarditis [J].
Cruz-Adalia, Aranzazu ;
Jesus Jimenez-Borreguero, Luis ;
Ramirez-Huesca, Marta ;
Chico-Calero, Isabel ;
Barreiro, Olga ;
Lopez-Conesa, Erica ;
Fresno, Manuel ;
Sanchez-Madrid, Francisco ;
Martin, Pilar .
CIRCULATION, 2010, 122 (14) :1396-+