Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer's Disease

被引:6
作者
Li, Na [1 ,2 ]
Li, Hongbo [2 ]
Liu, Zhenbin [2 ]
Feng, Gao [2 ]
Shi, Chunyang [2 ]
Wu, Yue [1 ]
机构
[1] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Changsha 410004, Peoples R China
[2] Shaanxi Univ Sci & Technol, Sch Food Sci & Engn, Xian 710021, Peoples R China
关键词
mushrooms; bioactive compounds; Alzheimer's disease; neuroprotection; EDIBLE CHINESE MUSHROOM; FLAMMULINA-VELUTIPES; MEDICINAL MUSHROOM; IN-VITRO; NEURITOGENIC CEREBROSIDES; COGNITIVE IMPAIRMENT; ANTIOXIDANT ACTIVITY; CYATHANE DITERPENES; NEURITE OUTGROWTH; WILD MUSHROOMS;
D O I
10.3390/foods12152972
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Alzheimer's disease (AD) stands as a prevailing neurodegenerative condition (NDs), leading to the gradual deterioration of brain cells and subsequent declines in memory, thinking, behavior, and emotion. Despite the intensive research efforts and advances, an effective curative treatment for the disease has not yet been found. Mushrooms, esteemed globally for their exquisite flavors and abundant nutritional benefits, also hold a wealth of health-promoting compounds that contribute to improving AD health. These compounds encompass polysaccharides, proteins, lipids, terpenoids, phenols, and various other bioactive substances. Particularly noteworthy are the potent neuroprotective small molecules found in mushrooms, such as ergothioneine, erinacine, flavonoids, alkaloids, ergosterol, and melanin, which warrant dedicated scrutiny for their therapeutic potential in combating AD. This review summarizes such positive effects of mushroom bioactive compounds on AD, with a hope to contribute to the development of functional foods as an early dietary intervention for this neurodegenerative disease.
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页数:18
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