Overcoming NMR line broadening of nitrogen containing compounds: A simple solution

This study presents a straightforward solution to the challenge of elucidating the structures of nitrogen containing compounds undergoing isomerization. When spectral line broadening occurs related to isomerization, be it prototropic tautomerism or bond rotations, this poses a significant obstacle to structural elucidation. By adding acids, we demonstrate a simple approach to overcome this issue and effectively sharpen NMR signals for acid stable prototropic tautomers as well as the conformational isomers containing a morpholine or piperazine ring. Unlocking isomerization mysteries: researchers in organic chemistry unveil a simple approach to resolve structural ambiguities arising from isomerization. By harnessing the power of acids, this innovative method enhances NMR signals, enabling precise characterization of acid-stable prototropic tautomers and conformational isomers with morpholine or piperazine rings. This work not only advances organic chemistry but also opens new horizons in structural elucidation, promising further revelations in molecular analysis.image