Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis

被引：11

作者：

Donlan, Alexandra N. ^{[1
]}

Mallawaarachchi, Indika ^{[2
]}

Sasson, Jennifer M. ^{[1
]}

Preissner, Robert ^{[3
,4
,5
,6
,7
]}

Loomba, Johanna J. ^{[8
]}

Petri, William A. ^{[1
,9
]}

机构：

[1] Univ Virginia, Sch Med, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA

[2] Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA

[3] Charite Univ Med Berlin, Sci IT, Berlin, Germany

[4] Charite Univ Med Berlin, Inst Physiol, Berlin, Germany

[5] Free Univ Berlin, Berlin, Germany

[6] Humboldt Univ, Berlin, Germany

[7] Berlin Inst Hlth, Berlin, Germany

[8] Integrated Translat Hlth Res Inst Virginia iTHR, Charlottesville, VA USA

[9] Univ Virginia, Sch Med, Dept Pathol, Charlottesville, VA 22908 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷 / 01期

基金：

美国国家卫生研究院;

关键词：

COVID-19; dupilumab; type; 2; immunity; infectious disease; INTERLEUKIN-13;

D O I：

10.1093/cid/ciac745

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We previously found that type 2 immunity promotes coronavirus disease 2019 (COVID-19) pathogenesis in a mouse model. To test relevance to human disease, we used electronic health record databases and determined that patients on dupilumab (anti-interleukin [IL]-4R monoclonal antibody that blocks IL-13 and IL-4 signaling) at the time of COVID-19 infection had lower mortality.

引用

页码：148 / 151

页数：4

共 12 条

[1] Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis [J].

Beck, Lisa A. ;

Thaci, Diamant ;

Hamilton, Jennifer D. ;

Graham, Neil M. ;

Bieber, Thomas ;

Rocklin, Ross ;

Ming, Jeffrey E. ;

Ren, Haobo ;

Kao, Richard ;

Simpson, Eric ;

Ardeleanu, Marius ;

Weinstein, Steven P. ;

Pirozzi, Gianluca ;

Guttman-Yassky, Emma ;

Suarez-Farinas, Mayte ;

Hager, Melissa D. ;

Stahl, Neil ;

Yancopoulos, George D. ;

Radin, Allen R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (02) :130-139

[2] Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma [J].

Castro, M. ;

Corren, J. ;

Pavord, I. D. ;

Maspero, J. ;

Wenzel, S. ;

Rabe, K. F. ;

Busse, W. W. ;

Ford, L. ;

Sher, L. ;

FitzGerald, J. M. ;

Katelaris, C. ;

Tohda, Y. ;

Zhang, B. ;

Staudinger, H. ;

Pirozzi, G. ;

Amin, N. ;

Ruddy, M. ;

Akinlade, B. ;

Khan, A. ;

Chao, J. ;

Martincova, R. ;

Graham, N. M. H. ;

Hamilton, J. D. ;

Swanson, B. N. ;

Stahl, N. ;

Yancopoulos, G. D. ;

Teper, A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (26) :2486-2496

[3] IL-13 is a driver of COVID-19 severity [J].

Donlan, Alexandra N. ;

Sutherland, Tara E. ;

Marie, Chelsea ;

Preissner, Saskia ;

Bradley, Ben T. ;

Carpenter, Rebecca M. ;

Sturek, Jeffrey M. ;

Ma, Jennie Z. ;

Moreau, G. Brett ;

Donowitz, Jeffrey R. ;

Buck, Gregory A. ;

Serrano, Myrna G. ;

Burgess, Stacey L. ;

Abhyankar, Mayuresh M. ;

Mura, Cameron ;

Bourne, Philip E. ;

Preissner, Robert ;

Young, Mary K. ;

Lyons, Genevieve R. ;

Loomba, Johanna J. ;

Ratcliffe, Sarah J. ;

Poulter, Melinda D. ;

Mathers, Amy J. ;

Day, Anthony ;

Mann, Barbara J. ;

Allen, Judith E. ;

Petri, William A., Jr. .

JCI INSIGHT, 2021, 6 (15)

[4]

Horby P, 2021, NEW ENGL J MED, V384, P693, DOI [10.1056/NEJMoa2021436, 10.1056/NEJMoa2022926]

[5]

Horby PW, 2021, LANCET, V397, P1637, DOI 10.1016/S0140-6736(21)00676-0

[6]

Iuliano AD., 2020, TRENDS DIS SEVERITY

[7] Safety and Efficacy of Dupilumab for the Treatment of Hospitalized Patients With Moderate to Severe Coronavirus Disease 2019: A Phase 2a Trial [J].

Sasson, Jennifer ;

Donlan, Alexandra N. ;

Ma, Jennie Z. ;

Haughey, Heather M. ;

Coleman, Rachael ;

Nayak, Uma ;

Mathers, Amy J. ;

Laverdure, Sylvain ;

Dewar, Robin ;

Jackson, Patrick E. H. ;

Heysell, Scott K. ;

Sturek, Jeffrey M. ;

Petri, William A., Jr. .

OPEN FORUM INFECTIOUS DISEASES, 2022, 9 (08)

[8] Interleukin-13 Stimulation Reveals the Cellular and Functional Plasticity of the Airway Epithelium [J].

Seibold, Max A. .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2018, 15 :S98-S102

[9] COVID-19 Symptoms Are Attenuated in Moderate-to-Severe Atopic Dermatitis Patients Treated with Dupilumab [J].

Ungar, Benjamin ;

Glickman, Jacob W. ;

Golant, Alexandra K. ;

Dubin, Celina ;

Marushchak, Olga ;

Gontzes, Alyssa ;

Mikhaylov, Daniela ;

Singer, Giselle K. ;

Baum, Danielle ;

Wei, Nancy ;

Sanin, Antonio ;

Gruenstein, Diana ;

Lebwohl, Mark G. ;

Pavel, Ana B. ;

Guttman-Yassky, Emma .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2022, 10 (01) :134-142

[10] Dupilumab in Persistent Asthma with Elevated Eosinophil Levels [J].

Wenzel, Sally ;

Ford, Linda ;

Pearlman, David ;

Spector, Sheldon ;

Sher, Lawrence ;

Skobieranda, Franck ;

Wang, Lin ;

Kirkesseli, Stephane ;

Rocklin, Ross ;

Bock, Brian ;

Hamilton, Jennifer ;

Ming, Jeffrey E. ;

Radin, Allen ;

Stahl, Neil ;

Yancopoulos, George D. ;

Graham, Neil ;

Pirozzi, Gianluca .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (26) :2455-2466

← 1 2 →