Effect of erythropoietin on cognitive side-effects of electroconvulsive therapy in depression: A randomized, double-blind, placebo-controlled trial

被引：7

作者：

Miskowiak, Kamilla W. ^{[1
,2
,3
]}

Petersen, Jeff Z. ^{[1
]}

Macoveanu, Julian ^{[1
]}

Ysbaek-Nielsen, Alexander T. ^{[1
,2
,3
]}

Lindegaard, Ida A. ^{[1
,2
,3
]}

Cramer, Katrine ^{[1
]}

Mogensen, Madel B. ^{[1
]}

Hammershoj, Lisa G. ^{[1
]}

Stougaard, Marie E. ^{[1
]}

Jorgensen, Josefine L. ^{[1
]}

Schmidt, Lejla Sjanic ^{[1
]}

Vinberg, Maj ^{[4
,5
]}

Ehrenreich, Hannelore ^{[6
]}

Hageman, Ida ^{[3
]}

Videbech, Poul ^{[4
,7
]}

Gbyl, Krzysztof ^{[4
,7
]}

Kellner, Charles H. ^{[8
]}

Kessing, Lars V. ^{[1
,4
]}

Jorgensen, Martin B. ^{[1
,4
]}

机构：

[1] Frederiksberg Univ Hosp, Copenhagen Affect Disorder Res Ctr CADIC, Psychiat Ctr Copenhagen, Mental Hlth Serv,Capital Reg Denmark, Copenhagen, Denmark

[2] Univ Copenhagen, Neurocognit & Emot Affect Disorders Ctr NEAD, Dept Psychol, Copenhagen, Denmark

[3] Capital Reg Denmark, Mental Hlth Serv, Copenhagen, Denmark

[4] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[5] Copenhagen Univ Hosp, Early Multimodular Prevent & Intervent Res Inst E, Mental Hlth Ctr, Mental Hlth Serv, Copenhagen, Denmark

[6] Max Planck Inst Multidisciplinary Sci, Clincial Neurosci, Gottingen, Germany

[7] Capital Reg Denmark, Mental Hlth Serv, Psychiat Ctr Glostrup, Copenhagen, Denmark

[8] Med Univ South Carolina, Dept Psychiat & Behav Sci, Charleston, SC USA

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2024年 / 79卷

关键词：

ECT; Cognition; Erythropoietin; Treatment; Randomized controlled trial; RETROGRADE AUTOBIOGRAPHICAL AMNESIA; RECOMBINANT-HUMAN-ERYTHROPOIETIN; ADULT NEUROGENESIS; BIPOLAR DISORDER; MEMORY RECALL; RATING-SCALE; MOOD; RELIABILITY; VALIDITY; VARIANTS;

D O I：

10.1016/j.euroneuro.2023.12.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Electroconvulsive therapy (ECT) is one of the most effective and rapid-acting treatment for severe depression but is associated with cognitive side-effects. Identification of add-on treatments that counteract these side-effects would be very helpful. This randomized, double-blinded, placebo-controlled, parallel-group study investigated the effects of four add-on erythropoietin (EPO; 40,000 IU/ml) or saline (placebo) infusions over 2.5 weeks of ECT (eight ECT sessions) in severely depressed patients with unipolar or bipolar depression. Neuropsychological assessments were conducted pre-ECT, three days after the eighth ECT (week 4), and at a 3-month follow-up. Further, functional magnetic resonance imaging (fMRI) was conducted after the eighth ECT. The primary outcome was change from pre- to post-ECT in a 'speed of complex cognitive processing' composite. Secondary outcomes were verbal and autobiographical memory. Of sixty randomized patients, one dropped out before baseline. Data were thus analysed for 59 patients (EPO, n = 33; saline, n = 26), of whom 28 had fMRI data. No ECT-related decline occurred in the primary global cognition measure (ps >= 0.1), and no effect of EPO versus saline was observed on this outcome (ps >= 0.3). However post-ECT, EPO-treated patients exhibited faster autobiographical memory recall than saline-treated patients (p = 0.02), which was accompanied by lower memoryrelated parietal cortex activity. The absence of global cognition changes with ECT and EPO, coupled with the specific impact of EPO on autobiographical memory recall speed and memory-related parietal cortex activity, suggests that assessing autobiographical memory may provide increased sensitivity in evaluating and potentially preventing cognitive side-effects of ECT. Trial registrations: ClinicalTrials.gov: NCT03339596, EudraCT no.: 2016-002326-36.

引用

页码：38 / 48

页数：11

共 77 条

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