The Impact of CoronaVac Vaccination on 28-day Mortality Rate of Critically Ill Patients with COVID-19 in Turkiye

被引：4

作者：

Gul, Fethi ^{[1
]}

Kasapoglu, Umut Sabri ^{[2
]}

Sabaz, Mehmet Suleyman ^{[3
]}

Ay, Pinar ^{[4
]}

Oktay, Burcin Doruk ^{[1
]}

Caliskan, Gulbahar ^{[5
]}

Demir, Nalan ^{[6
]}

Sayan, Ismet ^{[7
]}

Kabadayi, Feyyaz ^{[7
]}

Altuntas, Gulsum ^{[8
]}

Gumus, Ayca ^{[9
]}

Kirca, Huelya ^{[9
]}

Sanli, Deniz ^{[10
]}

Acil, Fatma ^{[11
]}

Dedeoglu, Andac ^{[11
]}

Ural, Sedef Gulcin ^{[12
]}

Sen, Irem Akin ^{[12
]}

Aydin, Eda Macit ^{[13
]}

Dayanir, Hakan ^{[13
]}

Yelken, Birgul ^{[14
]}

Ceylan, Ilkay ^{[15
]}

Aydin, Osman Ozcan ^{[14
]}

Eskidemir, Gunes ^{[16
]}

Aytekin, Ahmet ^{[17
]}

Cengiz, Melike ^{[18
]}

Arslan, Ulku ^{[18
]}

Akdag, Devrim ^{[19
]}

Alay, Gulcin Hilal ^{[20
]}

Tekin, Esra ^{[21
]}

Yarar, Volkan ^{[22
]}

Saracoglu, Kemal Tolga ^{[23
]}

Gok, Funda ^{[24
]}

Alparslan, Volkan ^{[25
]}

Tuna, Verda ^{[26
]}

Yildiz, Murside ^{[27
]}

Senoglu, Nimet ^{[28
]}

Kirakli, Cenk ^{[29
]}

Yildirim, Suleyman ^{[29
]}

Kubuc, Kubra Sacar ^{[30
]}

Erer, Aysen ^{[31
]}

Gultekin, Hamza ^{[32
]}

Suner, Kezban Ozmen ^{[33
]}

Kuzgun, Ozge ^{[33
]}

Ozturk, Cagatay Erman ^{[34
]}

Karahan, Aydin ^{[35
]}

Deveci, Okan ^{[35
]}

Ay, Mustafa ^{[36
]}

Oztan, Dilara Tufek ^{[36
]}

Akinci, Seda Banu ^{[37
]}

Solak, Melahat Yalcin ^{[37
]}

机构：

[1] Marmara Univ, Fac Med, Dept Anesthesiol & Reanimat, Div Crit Care Med, Istanbul, Turkiye

[2] Malatya Training & Res Hosp, Clin Crit Care Med, Malatya, Turkiye

[3] Marmara Univ, Pendik Training & Res Hosp, Clin Crit Care Med, Istanbul, Turkiye

[4] Marmara Univ, Fac Med, Dept Publ Hlth, Istanbul, Turkiye

[5] Univ Hlth Sci Turkiye, Bursa Fac Med, Dept Anesthesiol & Reanimat, Bursa, Turkiye

[6] Univ Hlth Sci Turkiye, Ankara City Hosp, Div Crit Care Med, Clin Chest Dis, Ankara, Turkiye

[7] Sancaktepe Training & Res Hosp, Clin Crit Care Med, Istanbul, Turkiye

[8] Elazig City Hosp, Clin Crit Care Med, Elazig, Turkiye

[9] Antalya Kepez State Hosp, Clin Crit Care Med, Antalya, Turkiye

[10] Batman Training & Res Hosp, Clin Crit Care Med, Batman, Turkiye

[11] Univ Hlth Sci Turkiye, Diyarbakir Gazi Yasargil Training & Res Hosp, Clin Anesthesiol & Reanimat, Diyabakir, Turkiye

[12] Univ Hlth Sci Turkiye, Erzurum City Hosp, Clin Crit Care Med, Erzurum, Turkiye

[13] Univ Hlth Sci Turkiye, Diskapi Yildirim Beyazit Training & Res Hosp, Div Crit Care Med, Clin Anesthesiol & Reanimat, Ankara, Turkiye

[14] Eskisehir Osmangazi Univ, Dept Anesthesiol & Reanimat, Div Crit Care Med, Fac Med, Eskisehir, Turkiye

[15] Univ Hlth Sci Turkiye, Bursa High Specializat Training & Res Hosp, Clin Crit Care Med, Bursa, Turkiye

[16] Gaziosmanpasa Training & Res Hosp, Clin Crit Care Med, Istanbul, Turkiye

[17] Goztepe Prof Dr Suleyman Yalcin City Hosp, Clin Anesthesiol & Reanimat, Istanbul, Turkiye

[18] Akdeniz Univ, Dept Anesthesiol & Reanimat, Div Crit Care Med, Fac Med, Antalya, Turkiye

[19] Univ Hlth Sci Turkiye, Adana City Hosp, Clin Crit Care Med, Adana, Turkiye

[20] Univ Hlth Sci Turkiye, Istanbul Basaksehir Cam & Sakura City Hosp, Dept Anesthesiol & Reanimat, Istanbul, Turkiye

[21] Denizli State Hosp, Clin Crit Care Med, Denizli, Turkiye

[22] Balikesir Ataturk City Hosp, Clin Crit Care Med, Balikesir, Turkiye

[23] Univ Hlth Sci Turkiye, Kartal Lutfi Kirdar Training & Res Hosp, Clin Anesthesiol & Reanimat, Istanbul, Turkiye

[24] Necmettin Erbakan Univ, Dept Anesthesiol & Reanimat, Div Crit Care Med, Fac Med, Konya, Turkiye

[25] Hatay Training & Res Hosp, Clin Crit Care Med, Hatay, Turkiye

[26] Adiyaman Training & Res Hosp, Clin Crit Care Med, Adiyaman, Turkiye

[27] Agri Training & Res Hosp, Clin Crit Care Med, Agri, Turkiye

[28] Univ Hlth Sci Turkiye, Tepecik Training & Res Hosp, Div Crit Care Med, Clin Anesthesiol & Reanimat, Izmir, Turkiye

[29] Univ Hlth Sci Turkiye, Dr Suat Seren Chest Dis & Thorac Surg Training & R, Dept Crit Care Med, Izmir, Turkiye

[30] Univ Hlth Sci Turkiye, Van Training & Res Hosp, Clin Crit Care Med, Van, Turkiye

[31] Tekirdag Ismail Fehmi Cumalioglu City Hosp, Clin Crit Care Med, Tekirdag, Turkiye

[32] Sirnak State Hosp, Clin Crit Care Med, Sirnak, Turkiye

[33] Sakarya Training & Res Hosp, Clin Crit Care Med, Sakarya, Turkiye

[34] Univ Hlth Sci Turkiye, Samsun Training & Res Hosp, Clin Crit Care Med, Samsun, Turkiye

[35] Mersin City Hosp, Clin Crit Care Med, Mersin, Turkiye

[36] Antalya Training & Res Hosp, Clin Anesthesiol & Reanimat, Antalya, Turkiye

[37] Hacettepe Univ, Dept Anesthesiol & Reanimat, Div Crit Care Med, Fac Med, Ankara, Turkiye

[38] Hitit Univ, Dept Anesthesiol & Reanimat, Div Crit Care Med, Fac Med, Corum, Turkiye

[39] Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Crit Care Med, Izmir, Turkiye

[40] Karadeniz Tech Univ, Dept Chest Dis, Div Crit Care Med, Fac Med, Trabzon, Turkiye

[41] Gaziantep Sehit Kamil State Hosp, Dept Crit Care Med, Gaziantep, Turkiye

[42] Gaziantep Univ, Dept Internal Med, Div Crit Care Med, Fac Med, Gaziantep, Turkiye

[43] Gazi Univ, Dept Internal Med, Div Crit Care Med, Fac Med, Ankara, Turkiye

[44] Cankiri State Hosp, Dept Crit Care Med, Cankiri, Turkiye

[45] Altunizade Acibadem Hosp, Dept Crit Care Med, Istanbul, Turkiye

[46] Sivas Numune Hosp, Dept Crit Care Med, Sivas, Turkiye

[47] Recep Tayyip Erdogan Univ, Dept Anesthesiol & Reanimat, Fac Med, Rize, Turkiye

[48] Univ Hlth Sci Turkiye, Istanbul Sureyyapasa Chest Dis & Thorac Surg Train, Dept Crit Care Med, Istanbul, Turkiye

[49] Amasya Univ Sabuncuoglu Serafettin Training & Res, Dept Crit Care Med, Amasya, Turkiye

[50] Univ Hlth Sci Turkiye, Izmir Bozyaka Training & Res Hosp, Dept Anesthesiol & Reanimat, Div Crit Care Med, Izmir, Turkiye

来源：

BALKAN MEDICAL JOURNAL | 2023年 / 40卷 / 06期

关键词：

AGED GREATER-THAN-OR-EQUAL-TO-65 YEARS; HEALTH-CARE WORKERS; STATES; HOSPITALIZATION; VACCINES; OUTCOMES;

D O I：

10.4274/balkanmedj.galenos.2023.2023-6-90

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Vaccines against coronavirus disease-19 (COVID-19) have been effective in preventing symptomatic diseases, hospitalizations, and intensive care unit (ICU) admissions. However, data regarding the effectiveness of COVID-19 vaccines in reducing mortality among critically ill patients with COVID-19 remains unclear.Aims: To determine the vaccination status and investigate the impact of the COVID-19 vaccine on the 28-day mortality in critically ill patients with COVID-19.Study Design: Multicenter prospective observational clinical study.Methods: This study was conducted in 60 hospitals with ICUs managing critically ill patients with COVID-19. Patients aged >= 18 years with confirmed COVID-19 who were admitted to the ICU were included. The present study had two phases. The first phase was designed as a one-day point prevalence study, and demographic and clinical findings were evaluated. In the second phase, the 28-day mortality was evaluated.Results: As of August 11, 2021, 921 patients were enrolled in the study. The mean age of the patients was 65.42 +/- 16.74 years, and 48.6% (n = 448) were female. Among the critically ill patients with COVID-19, 52.6% (n = 484) were unvaccinated, 7.7% (n = 71) were incompletely vaccinated, and 39.8% (n = 366) were fully vaccinated. A subgroup analysis of 817 patients who were unvaccinated (n = 484) or who had received two doses of the CoronaVac vaccine (n = 333) was performed. The 28-day mortality rate was 56.8% (n = 275) and 57.4% (n = 191) in the unvaccinated and two-dose CoronaVac groups, respectively. The 28-day mortality was associated with age, hypertension, the number of comorbidities, type of respiratory support, and APACHE II and sequential organ failure assessment scores (p < 0.05). The odds ratio for the 28-day mortality among those who had received two doses of CoronaVac was 0.591 (95% confidence interval: 0.413-0.848) (p = 0.004).Conclusion: Vaccination with at least two doses of CoronaVac within six months significantly decreased mortality in vaccinated patients than in unvaccinated patients.

引用

页码：435 / 444

页数：10

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