Epicardial Adipose Tissue in Myocardial Disease: From Physiology to Heart Failure Phenotypes

被引:14
作者
Antonopoulos, Alexios S. [1 ,2 ,3 ]
Papastamos, Charalampos [1 ]
Cokkinos, Dennis V. [2 ]
Tsioufis, Konstantinos [1 ]
Tousoulis, Dimitris [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Cardiol Dept 1, Athens, Greece
[2] Acad Athens, Clin Expt Surg & Translat Res Ctr, Biomed Res Fdn, Athens, Greece
[3] Hippokrateion Hosp, Cardiol Dept 1, Level 5,114 Vas Sofias Ave, Athens 11527, Greece
基金
欧盟地平线“2020”;
关键词
RIGHT-VENTRICULAR CARDIOMYOPATHY; FAT ATTENUATION INDEX; CARDIOVASCULAR-DISEASE; COMPUTED-TOMOGRAPHY; RISK-FACTORS; SYSTEMIC INFLAMMATION; INTRATHORACIC FAT; OXIDATIVE STRESS; PERICARDIAL FAT; OBESITY;
D O I
10.1016/j.cpcardiol.2023.101841
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Epicardial adipose tissue (EAT) is increasingly being recognized as a determinant of myocardial biology. The EAT-heart crosstalk suggests causal links between dysfunctional EAT and cardiomyocyte impairment. Obesity promotes EAT dysfunction and shifts in secreted adipokines which adversely affect tion, redox imbalance and myocardial fibrosis. Thus, EAT determines cardiac phenotype via effects on cardiac energetics, contractility, diastolic function, and atrial conduction. Vice-versa the EAT is altered in heart failure (HF), and such phenotypic changes can be detected by noninvasive imaging or incorporated in Artificial Intelligence-enhanced tools to aid the diagnosis, subtyping or risk prognostication of HF. In the present article, we summarize the links between EAT and the heart, explaining how the study of epicardial adiposity can improve the understanding of cardiac
引用
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页数:34
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