Between guidelines and clinical trials: evidence-based advice on the pharmacological management of non-specific chronic low back pain

被引：13
作者：
Migliorini, Filippo [1 ,2 ]
Vaishya, Raju [3 ]
Pappalardo, Gaetano [4 ]
Schneider, Marco [5 ,6 ]
Bell, Andreas [7 ]
Maffulli, Nicola [8 ,9 ,10 ]
机构：
[1] RWTH Univ Hosp Aachen, Dept Orthopaed Trauma & Reconstruct Surg, D-52064 Aachen, Germany
[2] Acad Hosp Bolzano SABES ASDAA, Dept Orthopaed & Trauma Surg, I-39100 Bolzano, Italy
[3] Indraprastha Apollo Hosp, Dept Orthoped, Inst Orthopaed, New Delhi, India
[4] Oberlinhaus, Dept Spine Surg, D-14482 Potsdam, Germany
[5] Univ Witten Herdecke, Dept Med & Dent, D-58455 Witten, Germany
[6] RWTH Univ Hosp Aachen, Dept Arthroscopy & Joint Replacement, MVZ Praxisklin Orthopadie Aachen, D-52074 Aachen, Germany
[7] Eifelklin St Brigida, Dept Orthoped, Simmerath, Germany
[8] Univ Salerno, Dept Med Surg & Dent, I-84081 Baronissi, Italy
[9] Queen Mary Univ London, Mile End Hosp, Barts & London Sch Med & Dent, London E1 4DG, England
[10] Keele Univ, Sch Pharm & Bioengn, Fac Med, Keele, England
来源：
BMC MUSCULOSKELETAL DISORDERS | 2023年 / 24卷 / 01期
关键词：
Spine; Low back pain; Chronic; Pharmacological therapy; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; ALPHA-LIPOIC ACID; BUPRENORPHINE TRANSDERMAL SYSTEM; OXYMORPHONE EXTENDED-RELEASE; NOXIOUS INHIBITORY CONTROL; OPIOID-NAIVE PATIENTS; DOUBLE-BLIND; CENTRAL SENSITIZATION;
D O I：
10.1186/s12891-023-06537-0
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
The pharmacological management of nonspecific chronic low back pain (NCLBP) aims to restore patients' daily activities and improve their quality of life. The management of NCLBP is not well codified and extremely heterogeneous, and residual symptoms are common. Pharmacological management should be considered as co-adjuvant to non-pharmacological therapy, and should be guided by the symptoms reported by the patients. Depending on the individual severity of NCLPB, pharmacological management may range from nonopioid to opioid analgesics. It is important to identify patients with generalized sensory hypersensitivity, who may benefit from dedicated therapy. This article provides an evidence-based overview of the principles of pharmacological management of NCLPB.
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页数：11
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