The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment

被引：7
|
作者：
Das, Sanjna [1 ]
Hayden, Joshua [2 ]
Sullivan, Travis [1 ]
Rieger-Christ, Kimberly [1 ]
机构：
[1] Lahey Hosp & Med Ctr, Dept Translat Res, Burlington, MA 01805 USA
[2] Lahey Hosp & Med Ctr, Dept Urol, Burlington, MA 01805 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 02期
关键词：
bladder cancer (BCa); recurrence; chemoresistance; miRNA; EMT; cell cycle; fatty acid metabolism; Wnt; HIPPO; FGFR3; EPITHELIAL-MESENCHYMAL TRANSITION; MICRORNA EXPRESSION SIGNATURES; MULTI-CHEMORESISTANCE; DOWN-REGULATION; CISPLATIN-RESISTANCE; CELL-PROLIFERATION; SIGNALING PATHWAY; NONINVASIVE BIOMARKERS; WNT/BETA-CATENIN; FGFR3; EXPRESSION;
D O I：
10.3390/ijms24020964
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bladder cancer (BCa) is associated with significant morbidity, with development linked to environmental, lifestyle, and genetic causes. Recurrence presents a significant issue and is managed in the clinical setting with intravesical chemotherapy or immunotherapy. In order to address challenges such as a limited supply of BCG and identifying cases likely to recur, it would be advantageous to use molecular biomarkers to determine likelihood of recurrence and treatment response. Here, we review microRNAs (miRNAs) that have shown promise as predictors of BCa recurrence. MiRNAs are also discussed in the context of predicting resistance or susceptibility to BCa treatment.
引用
收藏
页数：17
相关论文
共 50 条
  • [11] Endocrine resistance in breast cancer: Current status and a perspective on the roles of miRNAs (Review)
    Zhou, Jichun
    Teng, Rongyue
    Wang, Qinchuan
    Xu, Chenpu
    Guo, Jufeng
    Yuan, Chao
    Shen, Jianguo
    Hu, Wenxian
    Wang, Linbo
    Xie, Shuduo
    ONCOLOGY LETTERS, 2013, 6 (02) : 295 - 305
  • [12] Functional roles of exosomal miRNAs in multi-drug resistance in cancer chemotherapeutics
    Mowla, Mahshid
    Hashemi, Atieh
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2021, 118
  • [13] Natural compounds as modulators of miRNAs: a new frontier in bladder cancer treatment
    Abulsoud, Ahmed I.
    Aly, Shaza H.
    Mageed, Sherif S. Abdel
    Abdelmaksoud, Nourhan M.
    El-Dakroury, Walaa A.
    Mohammed, Osama A.
    Abdel-Reheim, Mustafa Ahmed
    Zaki, Mohamed Bakr
    Rizk, Nehal I.
    El Tabaa, Manar Mohammed
    Rashed, Mahmoud
    El-Shiekh, Riham A.
    Doghish, Ahmed S.
    MEDICAL ONCOLOGY, 2025, 42 (03)
  • [14] miRNAs and their roles in predicting length and timing of window of implantation
    Yang, E. P.
    Lee, Y. J.
    Cheng, E. H.
    Lin, P. Y.
    Chen, W. M.
    Hsu, W. C.
    Chang, P. C.
    Yang, J. H.
    Huang, Y. S.
    Fan, C. Y.
    Hsu, A.
    Kao, Y. C.
    Wang, T.
    Lee, M. S.
    HUMAN REPRODUCTION, 2022, 37 : I371 - I371
  • [15] Roles of non-coding RNAs in cell death pathways involved in the treatment of resistance and recurrence of cancer
    Motlagh, Fatemeh Movahedi
    Kadkhoda, Sepideh
    Motamedrad, Maryam
    Javidzade, Parisa
    Khalilian, Sheyda
    Modarressi, Mohammad Hossein
    Ghafouri-Fard, Soudeh
    PATHOLOGY RESEARCH AND PRACTICE, 2023, 247
  • [16] Hypoxia regulated miRNAs in bladder cancer
    Blick, C.
    Ramachandran, A.
    Cranston, D.
    Catto, J.
    Harris, A. L.
    BJU INTERNATIONAL, 2012, 109 : 25 - 25
  • [17] Postoperative nomogram predicting risk of recurrence after radical cystectomy for bladder cancer
    Bochner, Bernard H.
    Dalbagni, Guido
    Kattan, Michael W.
    Fearn, Paul
    Vora, Kinjal
    Seo, Hee Song
    Zoref, Lauren
    Abol-Enein, Hassan
    Ghoneim, Mohamed A.
    Bochner, Bernard H.
    Dalbagni, Guido
    Scardino, Peter T.
    Bajorin, Dean
    Skinner, Donald G.
    Stein, John P.
    Miranda, Gus
    Gschwend, Juergen E.
    Volkmer, Bjoern G.
    Hautmann, Richard E.
    Chang, Sam
    Cookson, Michael
    Smith, Joseph A.
    Thalman, George
    Studer, Urs E.
    Lee, Cheryl T.
    Montie, James
    Wood, David
    Puigvert, Fundacio
    Palou, Juan
    Fradet, Yyes
    LaCombe, Louis
    Simard, Pierre
    Schoenberg, Mark P.
    Lerner, Seth
    Vazina, Amnon
    Bassi, PierFrancesco
    Murai, Masaru
    Kikuchi, Eiji
    JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (24) : 3967 - 3972
  • [18] Predicting Nonmuscle Invasive Bladder Cancer Recurrence and Progression in a United States Population
    Ravvaz, Kourosh
    Walz, Marcus E.
    Weissert, John A.
    Downs, Tracy M.
    JOURNAL OF UROLOGY, 2017, 198 (04): : 824 - 831
  • [19] Nucleophosmin1 associated with drug resistance and recurrence of bladder cancer
    Hu, Huihui
    Meng, Qian
    Lei, Ting
    Zhang, Man
    CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 15 (03) : 361 - 369
  • [20] Nucleophosmin1 associated with drug resistance and recurrence of bladder cancer
    Huihui Hu
    Qian Meng
    Ting Lei
    Man Zhang
    Clinical and Experimental Medicine, 2015, 15 : 361 - 369
12345