In vitro Evaluation of DINCH-Plasticized Blood Bags for Red Blood Cell Storage with CPDA-1 Anticoagulant
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作者:
Kim, Hyungsuk
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Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Seoul Natl Univ Hosp, Dept Lab Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Kim, Hyungsuk
[1
,2
]
Lee, Kyunghoon
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Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam Si, South KoreaSeoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Lee, Kyunghoon
[1
,3
]
Seo, Soo Hyun
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Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam Si, South KoreaSeoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Seo, Soo Hyun
[1
,3
]
Hong, Yun Ji
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Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam Si, South KoreaSeoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Hong, Yun Ji
[1
,3
]
Hwang, Sang Mee
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Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam Si, South KoreaSeoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Hwang, Sang Mee
[1
,3
]
Park, Jeong Su
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Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam Si, South KoreaSeoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Park, Jeong Su
[1
,3
]
Park, Kyoung Un
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Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam Si, South KoreaSeoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Park, Kyoung Un
[1
,3
]
Song, Junghan
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Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam Si, South KoreaSeoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
Song, Junghan
[1
,3
]
机构:
[1] Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
[2] Seoul Natl Univ Hosp, Dept Lab Med, Seoul, South Korea
[3] Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam Si, South Korea
Introduction: Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in blood bags. Despite its protective effects on red blood cell (RBC) storage, concerns about its reproductive toxicity exist. This study investigated the in vitro quality of RBC concentrates stored in bags using di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) as an alternative plasticizer. Methods: Using a pool-and-split study design, we produced 20 matched homogenous quintets of RBC concentrates in two DINCH bags and three DEHP bags with citrate phosphate dextrose adenine (CPDA-1) anticoagulant. RBC storage quality was assessed weekly for 35 days. Results: On day 35, the median hemolysis levels in the DINCH bags (0.297-0.342%) were marginally higher (p < 0.05) than the DEHP bags (0.204-0.240%). All DINCH bags showed <0.8% hemolysis. RBCs in the DINCH bags showed increased mean corpuscular volume and decreased eosin 5 ' maleimide binding than in the DEHP bags. Higher pO(2) and lower pCO(2) levels in the DINCH bags indicated better gas permeability than in DEHP bags. Other metabolic parameters were comparable in both bags. Compared to DEHP, DINCH exhibited considerably lower levels of plasticizer leaching into blood bags. Conclusion: The quality of RBC concentrates stored for 35 days in DINCH-plasticized blood bags with CDPA-1 is generally comparable to those in DEHP bags. Hence, DINCH can be a viable alternative to DEHP in blood bags for nonleukoreduced RBC storage even without the use of next-generation additive solutions to improve RBC preservation quality.(c) 2024 The Author(s).Published by S. Karger AG, Basel
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Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Kuhikar, Rutuja
Khan, Nikhat
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Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Khan, Nikhat
Philip, Joseph
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Armed Forces Med Coll, Pune 411040, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Philip, Joseph
Melinkeri, Sameer
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Deenanath Mangeshkar Hosp, Blood & Marrow Transplant Unit, Pune 411004, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Melinkeri, Sameer
Kale, Vaijayanti
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Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Symbiosis Int Deemed Univ, Symbiosis Ctr Stem Cell Res, Sch Biol Sci, Pune 412115, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Kale, Vaijayanti
Limaye, Lalita
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Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
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Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Kuhikar, Rutuja
Khan, Nikhat
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Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Khan, Nikhat
Philip, Joseph
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Armed Forces Med Coll, Pune 411040, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Philip, Joseph
Melinkeri, Sameer
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Deenanath Mangeshkar Hosp, Blood & Marrow Transplant Unit, Pune 411004, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Melinkeri, Sameer
Kale, Vaijayanti
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Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Symbiosis Int Deemed Univ, Symbiosis Ctr Stem Cell Res, Sch Biol Sci, Pune 412115, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India
Kale, Vaijayanti
Limaye, Lalita
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Savitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, IndiaSavitribai Phule Pune Univ Campus, Natl Ctr Cell Sci, NCCS Complex, Pune 411007, Maharashtra, India