In vitro Evaluation of DINCH-Plasticized Blood Bags for Red Blood Cell Storage with CPDA-1 Anticoagulant

被引:1
作者
Kim, Hyungsuk [1 ,2 ]
Lee, Kyunghoon [1 ,3 ]
Seo, Soo Hyun [1 ,3 ]
Hong, Yun Ji [1 ,3 ]
Hwang, Sang Mee [1 ,3 ]
Park, Jeong Su [1 ,3 ]
Park, Kyoung Un [1 ,3 ]
Song, Junghan [1 ,3 ]
机构
[1] Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea
[2] Seoul Natl Univ Hosp, Dept Lab Med, Seoul, South Korea
[3] Seoul Natl Univ, Bundang Hosp, Dept Lab Med, Seongnam Si, South Korea
关键词
DEHP; DINCH; Plasticizer; Phthalate; Red blood cells; DI(2-ETHYLHEXYL) PHTHALATE; DI-2-ETHYLHEXYL PHTHALATE; WHOLE-BLOOD; QUALITY; DEHP; LEUKOREDUCTION; ALTERNATIVES; DIAGNOSIS; HEMOLYSIS; PRODUCTS;
D O I
10.1159/000535625
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in blood bags. Despite its protective effects on red blood cell (RBC) storage, concerns about its reproductive toxicity exist. This study investigated the in vitro quality of RBC concentrates stored in bags using di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) as an alternative plasticizer. Methods: Using a pool-and-split study design, we produced 20 matched homogenous quintets of RBC concentrates in two DINCH bags and three DEHP bags with citrate phosphate dextrose adenine (CPDA-1) anticoagulant. RBC storage quality was assessed weekly for 35 days. Results: On day 35, the median hemolysis levels in the DINCH bags (0.297-0.342%) were marginally higher (p < 0.05) than the DEHP bags (0.204-0.240%). All DINCH bags showed <0.8% hemolysis. RBCs in the DINCH bags showed increased mean corpuscular volume and decreased eosin 5 ' maleimide binding than in the DEHP bags. Higher pO(2) and lower pCO(2) levels in the DINCH bags indicated better gas permeability than in DEHP bags. Other metabolic parameters were comparable in both bags. Compared to DEHP, DINCH exhibited considerably lower levels of plasticizer leaching into blood bags. Conclusion: The quality of RBC concentrates stored for 35 days in DINCH-plasticized blood bags with CDPA-1 is generally comparable to those in DEHP bags. Hence, DINCH can be a viable alternative to DEHP in blood bags for nonleukoreduced RBC storage even without the use of next-generation additive solutions to improve RBC preservation quality.(c) 2024 The Author(s).Published by S. Karger AG, Basel
引用
收藏
页码:274 / 285
页数:12
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