Probing when dCas9 tolerates DNA mismatches

被引：0
|
作者：
Guan, Weihua [1 ]
机构：
[1] Penn State Univ, Dept Elect Engn & Biomed Engn, University Pk, PA 16802 USA
来源：
NATURE BIOMEDICAL ENGINEERING | 2024年 / 8卷 / 03期
关键词：
DNA sequences;
D O I：
10.1038/s41551-023-01172-5
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Sensing changes in ionic current as barcoded DNA translocates through solid-state nanopores allows the study of how nucleotide sequences alter the DNA-binding specificity of the catalytically inactive Cas9 ribonucleoprotein complex.
引用
收藏
页码：207 / 208
页数：2
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