COVID-19 is more lethal in hemodialysis chronic kidney disease patients with low physical capacity

Introduction: The mortality rate in patients on maintenance hemodialysis (HD) is high and is associated with low functional capacity (FC). We analyzed the association of FC and COVID-19 lethality among HD patients. Methods: A cohort study that included evaluations of FC in patients on HD was underway, and the association between FC and lethality was included as an ad-hoc outcome. Results: One hundred and twelve patients were submitted to a physical, 31 patients contracted symptomatic COVID-19, 20 recovered and 11 died (lethality rate of 35.5%). There was a difference between survivors and non-survivors on six-minutes-walking-test (6MWT) 386.1 +/- 112.8 versus 296.9 +/- 103.3 meters (p = 0.04), 30 s sit-to-stand test (30CST) score 11.7 +/- 3.1 versus 7.7 +/- 4.1 (p = 0.006), and timed up and go test (TUG) 9.4 versus 13.6 s (p = 0.009). There was also an association between percentages of predicted 6MWT, 30CST, and TUG with COVID-19 lethality. Conclusion: Patients on maintenance HD with poorer physical performance presented the worst prognosis from COVID-19 pandemic.