Recent advances in novel miRNA mediated approaches for targeting breast cancer

被引：11

作者：

Ahmadi, Seyedeh Melika ^{[1
]}

Amirkhanloo, Shervin ^{[1
]}

Yazdian-Robati, Rezvan ^{[2
]}

Ebrahimi, Hossein ^{[1
]}

Pirhayati, Faezeh Hosseini ^{[3
]}

Almalki, Waleed H. ^{[4
]}

Ebrahimnejad, Pedram ^{[1
,2
]}

Kesharwani, Prashant ^{[5
,6
,7
]}

机构：

[1] Mazandaran Univ Med Sci, Fac Pharm, Dept Pharmaceut, Sari, Iran

[2] Mazandaran Univ Med Sci, Hemoglobinopathy Inst, Pharmaceut Sci Res Ctr, Sari, Iran

[3] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[4] Umm Al Qura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mecca, Saudi Arabia

[5] Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi, India

[6] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Dent Coll, Dept Pharmacol, Chennai, India

[7] Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India

来源：

JOURNAL OF DRUG TARGETING | 2023年 / 31卷 / 08期

关键词：

miRNA; breast cancer; polymer; biomarkers; cancer; drug delivery; MESOPOROUS SILICA NANOPARTICLES; CO-DELIVERY; CELL-PROLIFERATION; GOLD NANOPARTICLE; TUMOR-SUPPRESSOR; POLYMER NANOPARTICLES; SYSTEMIC DELIVERY; DOWN-REGULATION; PROMOTES; RESISTANCE;

D O I：

10.1080/1061186X.2023.2240979

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Breast cancer (BC) is considered one of the most frequent cancers among woman worldwide. While conventional therapy has been successful in treating many cases of breast cancer, drug resistance, heterogenicity, tumour features and recurrence, invasion, metastasis and the presence of breast cancer stem cells can hinder the effect of treatments, and can reduce the quality of life of patients. MicroRNAs (miRNAs) are short non-coding RNA molecules that play a crucial role in the development and progression of breast cancer. Several studies have reported that aberrant expression of specific miRNAs is associated with the pathogenesis of breast cancer. However, miRNAs are emerging as potential biomarkers and therapeutic targets for breast cancer. Understanding their role in breast cancer biology could help develop more effective treatments for this disease. The present study discusses the biogenesis and function of miRNAs, as well as miRNA therapy approaches for targeting and treating breast cancer cells.

引用

页码：777 / 793

页数：17

共 178 条

[1] Multifunctional stimuli-responsive niosomal nanoparticles for co-delivery and co-administration of gene and bioactive compound: In vitro and in vivo studies [J].

Abtahi, Najmeh Alsadat ;

Naghib, Seyed Morteza ;

Ghalekohneh, Sina Jafari ;

Mohammadpour, Zahra ;

Nazari, Hojjatollah ;

Mosavi, Seyed Mohammad ;

Gheibihayat, Seyed Mohammad ;

Haghiralsadat, Fateme ;

Reza, Javad Zavar ;

Doulabi, Behroz Zandieh .

CHEMICAL ENGINEERING JOURNAL, 2022, 429

[2]

Agboola R., 2023, Adv. Res., V24, P1

[3] Delivery of dual miRNA through CD44-targeted mesoporous silica nanoparticles for enhanced and effective triple-negative breast cancer therapy [J].

Ahir, Manisha ;

Upadhyay, Priyanka ;

Ghosh, Avijit ;

Sarker, Sushmita ;

Bhattacharya, Saurav ;

Gupta, Payal ;

Ghosh, Swatilekha ;

Chattopadhyay, Sreya ;

Adhikary, Arghya .

BIOMATERIALS SCIENCE, 2020, 8 (10) :2939-2954

[4] In-Silico Target Prediction for hsa-mir-27a and Identification of Genes Involved in Breast Cancer [J].

Ahmad, Mushtaq ;

Shah, Aftab Ali .

INTERNATIONAL JOURNAL OF HUMAN GENETICS, 2019, 19 (01) :12-21

[5] Improved delivery of miR-1296 loaded cationic nanoliposomes for effective suppression of triple negative breast cancer [J].

Albakr, Lamyaa ;

Alqahtani, Fulwah Yahya ;

Aleanizy, Fadilah Sfouq ;

Alomrani, Abdullah ;

Badran, Mohammad ;

Alhindas, Hussein ;

Al-Mohanna, Futwan .

SAUDI PHARMACEUTICAL JOURNAL, 2021, 29 (05) :446-455

[6] microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis [J].

Annese, Tiziana ;

Tamma, Roberto ;

De Giorgis, Michelina ;

Ribatti, Domenico .

FRONTIERS IN ONCOLOGY, 2020, 10

[7] Current and future burden of breast cancer: Global statistics for 2020 and 2040 [J].

Arnold, Melina ;

Morgan, Eileen ;

Rumgay, Harriet ;

Mafra, Allini ;

Singh, Deependra ;

Laversanne, Mathieu ;

Vignat, Jerome ;

Gralow, Julie R. ;

Cardoso, Fatima ;

Siesling, Sabine ;

Soerjomataram, Isabelle .

BREAST, 2022, 66 :15-23

[8] A novel MUC1 aptamer-modified PLGA-epirubicin-PβAE-antimir-21 nanocomplex platform for targeted co-delivery of anticancer agents in vitro and in vivo [J].

Bahreyni, Amirhossein ;

Alibolandi, Mona ;

Ramezani, Mohammad ;

Sadeghi, Atefeh Sarafan ;

Abnous, Khalil ;

Taghdisi, Seyed Mohammad .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 175 :231-238

[9] Impact of circulating miRNA-373 on breast cancer diagnosis through targeting VEGF and cyclin D1 genes [J].

Bakr, Noha M. ;

Mahmoud, Magda Sayed ;

Nabil, Reem ;

Boushnak, Hussein ;

Swellam, Menha .

JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY, 2021, 19 (01)

[10] Delivery of therapeutic miRNA using polymer-based formulation [J].

Ban, Eunmi ;

Kwon, Taek-Hyun ;

Kim, Aeri .

DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2019, 9 (06) :1043-1056

← 1 2 3 4 5 6 7 8 9 10 →