Novel 5,6,7,8-tetrahydrobenzo[b]pyran Derivatives: Synthesis and Anticancer Activity

被引：1

作者：

Abdallah, Amira E. M. ^{[1
]}

Mohareb, Rafat M. ^{[2
]}

Helal, Maher H. E. ^{[1
]}

Abd Elkader, Mariam M. ^{[1
]}

机构：

[1] Helwan Univ, Fac Sci, Dept Chem, Cairo 11795, Egypt

[2] Cairo Univ, Fac Sci, Dept Chem, Giza 12614, Egypt

来源：

ACTA CHIMICA SLOVENICA | 2023年 / 70卷 / 02期

关键词：

Tetrahydrobenzo[b]pyran; thiophene; pyridine; anti-proliferative activity; ONE-POT SYNTHESIS; EFFICIENT; THIOPHENE; ACID;

D O I：

10.17344/acsi.2022.7893

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran systems showed high reactivity to various chemical reagents. 24 products of the prepared compounds were chosen and tested in (mM) as respectable anticancer factors. The findings revealed that compounds 3b, 6b, and 8 were the widely effective compounds against the three cancer cell lines including A-549 (lung carcinoma), HC-29 (colorectal adenocarcinoma), and MKN-45 (gastric cancer) compared to the standard reference control foretinib.

引用

页码：261 / 273

页数：13

共 34 条

[1] Synthesis and Anticancer Evaluations of Novel Thiazole Derivatives Derived from 4-Phenylthiazol-2-amine
Abdallah, Amira E. M.
Mohareb, Rafat M.
Helal, Maher H. E.
Mofeed, Germeen J.
[J]. ACTA CHIMICA SLOVENICA, 2021, 68 (03) : 604 - 616
[2] Novel Pyrano[2,3-d]thiazole and Thiazolo[4,5-b]pyridine Derivatives: One-pot Three-component Synthesis and Biological Evaluation as Anticancer Agents, c-Met, and Pim-1 Kinase Inhibitors
Abdallah, Amira E. M.
Mohareb, Rafat M.
Ahmed, Ebtsam A.
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (11) : 3017 - 3029
[3] Uses of 4,4-dicyano-3-phenyl-but-3-enoic acid phenylamide for the synthesis of new compounds: antimicrobial and textile finishing evaluations
Abdallah, Amira E. M.
Mohareb, Rafat M.
[J]. PIGMENT & RESIN TECHNOLOGY, 2019, 48 (02) : 89 - 107
[4] Artizzu N, 1995, FARMACO, V50, P853
[5] Ashok D, 2006, HETEROCYCL COMMUN, V12, P103
[6] A choline chloride-based deep eutectic solvent promoted three-component synthesis of tetrahydrobenzo[b]pyran and pyrano[2,3-d] pyrimidinone (thione) derivatives
Biglari, Mohammad
Shirini, Farhad
Mahmoodi, Nosrat O.
Zabihzadeh, Mehdi
Mashhadinezhad, Maryam
[J]. JOURNAL OF MOLECULAR STRUCTURE, 2020, 1205
[7] SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 2-OXO-(2H) 1-BENZOPYRAN-3-CARBOXAMIDE DERIVATIVES
BONSIGNORE, L
LOY, G
SECCI, D
CALIGNANO, A
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1993, 28 (06) : 517 - 520
[8] Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1-benzopyran-3-carboxamides and their 2-iminoanalogues
Bylov, IE
Vasylyev, MV
Bilokin, YV
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1999, 34 (11) : 997 - 1001
[9] Sodium bromide catalysed one-pot synthesis of tetrahydrobenzo[b]pyrans via a three-component cyclocondensation under microwave irradiation and solvent free conditions
Devi, I
Bhuyan, PJ
[J]. TETRAHEDRON LETTERS, 2004, 45 (47) : 8625 - 8627
[10] Catalyst-free UV365-assisted synthesis of pyran annulated heterocyclic scaffolds and evaluation of their antibacterial activities
Dutta, Arup
Rahman, Noimur
Kumar, John Elisa
Rabha, Jintu
Phukan, Tridip
Nongkhlaw, Rishanlang
[J]. SYNTHETIC COMMUNICATIONS, 2021, 51 (02) : 263 - 278

← 1 2 3 4 →