Association of CD34+Cell Dose with Progression-free Survival after Allogeneic Peripheral Blood Hematopoietic Cell Transplantation in Children with Hematologic Malignancies

被引：0

作者：

Wang, Yi-Lun ^{[1
]}

Chang, Tsung-Yen ^{[1
,2
]}

Hsieh, Hsin-Yi ^{[3
]}

Chen, Shih-Hsiang ^{[1
,2
]}

Wen, Yu-Chuan ^{[4
]}

Chiu, Chia-Chi ^{[4
]}

Jaing, Tang-Her ^{[1
,2
,5
]}

机构：

[1] Linkou Chang Gung Mem Hosp, Dept Pediat, Taoyuan, Taiwan

[2] Linkou Chang Gung Mem Hosp, Div Hematol Oncol, Taoyuan, Taiwan

[3] Kaohsiung Chang Gung Mem Hosp, Dept Hematol Oncol, Dept Pediat, Kaohsiung, Taiwan

[4] Linkou Chang Gung Mem Hosp, Dept Nursing, Taoyuan, Taiwan

[5] Chang Gung Univ, Chang Gung Childrens Hosp, Dept Pediat, Div Hematol & Oncol, 5 Fu Shin St, Taoyuan 33305, Taiwan

来源：

TRANSPLANTATION PROCEEDINGS | 2023年 / 55卷 / 02期

关键词：

ACUTE MYELOID-LEUKEMIA; UNRELATED DONOR; DISEASE; IMPACT;

D O I：

10.1016/j.transproceed.2023.01.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. A higher CD34+ cell dose is associated with improved engraftment but may also be associated with an increased risk of complications after allogeneic hematopoietic stem cell transplantation, including graft-versus-host disease (GVHD). Methods. We retrospectively analyze the impact of CD34+ cell dose on OS, PFS, neutrophil engraftment, platelet engraftment, treatment-related mortality, and GVHD grading.Results. For analyses, CD34+ cell dose was stratified into low (< 8.5 pound 106/kg) and high (> 8.5 pound 106/kg). A subgroup analysis of higher CD34+ cell dose leads to prolonged OS and PFS, but statistical significance was achieved only for PFS (OR 0.36; 95%CI 0.14-0.95; P= 0.04).Conclusions. This study reinforced that CD34+ cell dose at the time of allo-HSCT retained a positive impact on PFS.

引用

页码：481 / 484

页数：4

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