New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26

被引：6

作者：

Wang, Pei ^{[1
,2
]}

Wang, Huifang ^{[1
]}

Yang, Juchun ^{[1
]}

Yang, Li ^{[1
]}

Cai, Caihong ^{[1
]}

Yuan, Jingzhe ^{[1
]}

Wu, Fei ^{[1
]}

Gai, Cuijuan ^{[1
]}

Mei, Wenli ^{[1
]}

Dai, Haofu ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Hainan Inst Trop Agr Resources, Inst Trop Biosci & Biotechnol, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China

[2] Guangxi Minzu Univ, Sch Chem & Chem Engn, Nanning 530000, Peoples R China

来源：

MARINE DRUGS | 2023年 / 21卷 / 03期

基金：

海南省自然科学基金;

关键词：

isocoumarins; marine fungus; Phaeosphaeriopsis sp; neuroprotective effect; cytotoxicity; PIMARANE DITERPENES;

D O I：

10.3390/md21030150

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new isocoumarins, phaeosphaerins A-E (1-5), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (6), and two known pimarane-type diterpenes, diaportheins A (7) and B (8). Their structures were elucidated via NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds 1-7 displayed weak neuroprotective effects against H2O2-induced damage in SH-SY5Y cells. Moreover, compound 8 showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines.

引用

页数：11

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