Large animal models for cardiac remuscularization studies: A methodological review

被引:3
作者
Yu, Yuexin [1 ,2 ,3 ]
Tham, Seng Kong [4 ]
Roslan, Fatin Fazrina [1 ]
Shaharuddin, Bakiah [1 ]
Yong, Yoke Keong [5 ]
Guo, Zhikun [2 ,3 ]
Tan, Jun Jie [1 ]
机构
[1] Univ Sains Malaysia, Adv Med & Dent Inst, USM ALPS Cardiac Res Lab, George Town, Malaysia
[2] Zhengzhou Seventh Peoples Hosp, Henan Key Lab Cardiac Remodeling & Transplantat, Zhengzhou, Peoples R China
[3] Xinxiang Med Univ, Henan Key Lab Med Tissue Regenerat, Urumqi, Peoples R China
[4] Celestialab Sdn Bhd, Kuala Lumpur, Malaysia
[5] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Human Anat, Serdang, Malaysia
关键词
cardiac regeneration; large animal models; pluripotent stem cells (PSC); cardiomyocytes; cardiac remuscularization; myocardial infarction; MESENCHYMAL STEM-CELLS; PERCUTANEOUS CORONARY INTERVENTION; ACUTE MYOCARDIAL-INFARCTION; ACTIVATED CLOTTING TIME; MARROW STROMAL CELLS; PORCINE MODEL; MYCOPHENOLATE-MOFETIL; ISCHEMIA-REPERFUSION; VENTRICULAR-FUNCTION; HEART-FAILURE;
D O I
10.3389/fcvm.2023.1011880
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Myocardial infarction is the most common cause of heart failure, one of the most fatal non-communicable diseases worldwide. The disease could potentially be treated if the dead, ischemic heart tissues are regenerated and replaced with viable and functional cardiomyocytes. Pluripotent stem cells have proven the ability to derive specific and functional cardiomyocytes in large quantities for therapy. To test the remuscularization hypothesis, the strategy to model the disease in animals must resemble the pathophysiological conditions of myocardial infarction as in humans, to enable thorough testing of the safety and efficacy of the cardiomyocyte therapy before embarking on human trials. Rigorous experiments and in vivo findings using large mammals are increasingly important to simulate clinical reality and increase translatability into clinical practice. Hence, this review focus on large animal models which have been used in cardiac remuscularization studies using cardiomyocytes derived from human pluripotent stem cells. The commonly used methodologies in developing the myocardial infarction model, the choice of animal species, the pre-operative antiarrhythmics prophylaxis, the choice of perioperative sedative, anaesthesia and analgesia, the immunosuppressive strategies in allowing xenotransplantation, the source of cells, number and delivery method are discussed.
引用
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页数:17
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