Clinical implications of Golgi protein 73 and granulocyte colony-stimulating factor and their related factors in children with bronchopneumonia

Objective: To investigate the clinical implications of Golgi glycoprotein 73 (GP73) and granulo-cyte colony-stimulating factor (G-CSF) in children with bronchopneumonia (BP).Methods: Seventy-two children with BP (observation group) and 81 healthy children (control group) consecutively brought to the present study's hospital between June 2019 and October 2020 were enrolled. GP73 and G-CSF levels were determined to analyze their diagnostic value for pediatric BP. High-sensitivity C-reactive protein (hs-CRP) was also measured. The clinical implications of GP73 and G-CSF in pediatric BP complicated with respiratory failure and their connections with the inflammatory response were discussed.Results: GP73 and G-CSF levelswere remarkably higherin theobservation group (p< 0.05). The sensitiv-ity and specificity of combined detection (GP73+G-CSF) in predicting pediatric BP were 72.22% and 86.42%, respectively (p < 0.001). GP73 and G-CSF, which are closely related to X-ray classification and complications in the observation group, decreased after treatment and were positively correlated with hs-CRP (p < 0.05), especially in children complicated with respiratory failure. Regression analysisidenti-fied the independence of the course of the disease, hs-CRP, X-ray classification, GP73, and G-CSF as influ-encing factors of respiratoryfailurein children with BP (p < 0.05).Conclusion: GP73 and G-CSF, with elevated levels in children with BP, are strongly linked to dis-ease progression and are independent influencing factors of respiratory failure, which may be the key to diagnosing and treating pediatric BP in the future.(c) 2022 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/).