Role of microbiota and microbiota-derived short-chain fatty acids in PDAC

被引：13

作者：

Temel, Hulya Yilmaz ^{[1
]}

Kaymak, Oznur ^{[1
]}

Kaplan, Seren ^{[1
]}

Bahcivanci, Basak ^{[2
]}

Gkoutos, Georgios V. ^{[2
,3
,4
]}

Acharjee, Animesh ^{[2
,3
,4
]}

机构：

[1] Ege Univ, Dept Bioengn, Fac Engn, Izmir, Turkey

[2] Univ Birmingham, Inst Canc & Genom Sci, Birmingham, W Midlands, England

[3] Queen Elizabeth Hosp Birmingham, Natl Inst Hlth Res Surg Reconstruct, Birmingham, W Midlands, England

[4] MRC Hlth Data Res UK HDR UK, Birmingham, W Midlands, England

来源：

CANCER MEDICINE | 2023年 / 12卷 / 05期

基金：

英国科研创新办公室; 欧盟地平线“2020”;

关键词：

host-microbe interactions; inflammation; microbiome; microbiota; pancreatic ductal adenocarcinoma; SCFA; PANCREATIC DUCTAL ADENOCARCINOMA; KAPPA-B ACTIVATION; SODIUM-BUTYRATE; GUT MICROBIOTA; TUMOR MICROBIOME; BACTERIAL TRANSLOCATION; INTESTINAL MICROBIOTA; COLONIC INFLAMMATION; METABOLITE BUTYRATE; HELICOBACTER-PYLORI;

D O I：

10.1002/cam4.5323

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive lethal diseases among other cancer types. Gut microbiome and its metabolic regulation play a crucial role in PDAC. Metabolic regulation in the gut is a complex process that involves microbiome and microbiome-derived short-chain fatty acids (SCFAs). SCFAs regulate inflammation, as well as lipid and glucose metabolism, through different pathways. This review aims to summarize recent developments in PDAC in the context of gut and oral microbiota and their associations with short-chain fatty acid (SCFA). In addition to this, we discuss possible therapeutic applications using microbiota in PDAC.

引用

页码：5661 / 5675

页数：15

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