Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae

被引：12

作者：

Cui, Qiaozhen ^{[1
]}

Wang, Chen ^{[2
]}

Wang, Qichen ^{[2
]}

Qin, Juanxiu ^{[2
]}

Li, Min ^{[2
]}

Ding, Baixing ^{[3
,4
,6
]}

Shen, Zhen ^{[2
,5
]}

机构：

[1] Shanxi Bethune Hosp, Taiyuan, Peoples R China

[2] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai, Peoples R China

[3] Fudan Univ, Shanghai Minist Hlth, Huashan Hosp, Shanghai, Peoples R China

[4] Minist Hlth, Key Lab Clin Pharmacol Antibiot, Shanghai, Peoples R China

[5] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Lab Med, 160 Pujian Rd, Shanghai, Peoples R China

[6] Fudan Univ, Huashan Hosp, Inst Antibiot, 12 Wulumuqi Rd, Shanghai, Peoples R China

来源：

EMERGING INFECTIOUS DISEASES | 2023年 / 29卷 / 11期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.3201/eid2911.230830

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for blaSHV-12, leading to blaSHV-12 overexpression and ment contributed to convergence of hypervirulence and ceftazidime/avibactam resistance.

引用

收藏

页码：2398 / 2400

页数：3

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