Expanding our grasp of two-component signaling in Clostridioides difficile

被引：1
|
作者：
Alvarez, Orlando Berumen [1 ]
Purcell, Erin B. [1 ]
Henkin, Tina M.
机构：
[1] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23508 USA
来源：
JOURNAL OF BACTERIOLOGY | 2023年 / 205卷 / 10期
基金：
美国国家科学基金会;
关键词：
Clostridioides difficile; two-component signaling; LOCUS; GENE;
D O I：
10.1128/jb.00188-23
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023, https://doi.org/10.1128/jb.00164-23) have identified both for the novel C. difficile TCD DraRS. DraRS responds to antibiotics that target lipid-II molecules in the bacterial cell envelope, and regulates the production of a novel glycolipid necessary for bacitracin and daptomycin resistance in C. difficile.
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