Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae

被引:9
作者
Rass, Verena [1 ]
Tymoszuk, Piotr [2 ]
Sahanic, Sabina [3 ]
Heim, Beatrice [1 ]
Ausserhofer, Dietmar [4 ]
Lindner, Anna [1 ]
Kofler, Mario [1 ]
Mahlknecht, Philipp [1 ]
Boehm, Anna [3 ]
Huefner, Katharina [5 ]
Pizzini, Alex [3 ]
Sonnweber, Thomas [3 ]
Kurz, Katharina [3 ]
Pfeifer, Bernhard [6 ,7 ]
Kiechl, Stefan [1 ]
Peball, Marina [1 ]
Kindl, Philipp [1 ]
Putnina, Lauma [1 ]
Fava, Elena [1 ]
Djamshidian, Atbin [1 ]
Huber, Andreas [6 ]
Wiedermann, Christian J. [4 ]
Sperner-Unterweger, Barbara [5 ]
Woell, Ewald [8 ]
Beer, Ronny [1 ]
Schiefecker, Alois Josef [1 ]
Bellmann-Weiler, Rosa [3 ]
Bachler, Herbert [9 ]
Tancevski, Ivan [3 ]
Pfausler, Bettina [1 ]
Piccoliori, Giuliano [4 ]
Seppi, Klaus [1 ]
Weiss, Guenter [3 ]
Loeffler-Ragg, Judith [3 ]
Helbok, Raimund [1 ,10 ]
机构
[1] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria
[2] Data Analyt Serv Tirol, Innsbruck, Austria
[3] Med Univ Innsbruck, Dept Internal Med 2, Innsbruck, Austria
[4] Claudiana Coll Hlth Profess, Inst Gen Practice & Publ Hlth, Bolzano, Italy
[5] Med Univ Innsbruck, Univ Hosp Psychiat 2, Dept Psychiat Psychotherapy Psychosomat & Med Psy, Innsbruck, Austria
[6] Tyrolean Fed Inst Integrated Care, Innsbruck, Austria
[7] UMIT, Div Hlth Networking & Telehlth Biomed Informat &, Hall In Tirol, Austria
[8] St Vinzenz Hosp, Dept Internal Med, Zams, Austria
[9] Med Univ Innsbruck, Inst Gen Med, Innsbruck, Austria
[10] Johannes Kepler Univ Linz, Dept Neurol, Linz, Austria
关键词
Olfactory dysfunction; Smell and taste disorder; Long COVID; Post-COVID-19; condition; Mental health; Quality of life;
D O I
10.1007/s00405-023-08163-x
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
PurposeOlfactory dysfunction (OD) commonly accompanies coronavirus disease 2019 (COVID-19). We investigated the kinetics of OD resolution following SARS-CoV-2 infection (wild-type and alpha variant) and its impact on quality of life, physical and mental health.MethodsOD prevalence was assessed in an ambulatory COVID-19 survey (n = 906, >= 90 days follow-up) and an observational cohort of ambulatory and hospitalized individuals (n = 108, 360 days follow-up). Co-occurrence of OD with other symptoms and effects on quality of life, physical and mental health were analyzed by multi-dimensional scaling, association rule mining and semi-supervised clustering.ResultsBoth in the ambulatory COVID-19 survey study (72%) and the observational ambulatory and hospitalized cohort (41%) self-reported OD was frequent during acute COVID-19. Recovery from self-reported OD was slow (survey: median 28 days, observational cohort: 90 days). By clustering of the survey data, we identified a predominantly young, female, comorbidity-free group of convalescents with persistent OD and taste disorders (median recovery: 90 days) but low frequency of post-acute fatigue, respiratory or neurocognitive symptoms. This smell and taste disorder cluster was characterized by a high rating of physical performance, mental health, and quality of life as compared with convalescents affected by prolonged fatigue or neurocognitive complaints.ConclusionOur results underline the heterogeneity of post-acute COVID-19 sequelae calling for tailored management strategies. The persistent smell and taste disorder phenotype is characterized by good clinical, physical, and mental recovery and may pose a minor challenge for public health.Study registrationClinicalTrials.gov: NCT04661462 (survey study), NCT04416100 (observational cohort).
引用
收藏
页码:5115 / 5128
页数:14
相关论文
共 45 条
[21]   Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients [J].
Lechien, J. R. ;
Chiesa-Estomba, C. M. ;
Beckers, E. ;
Mustin, V ;
Ducarme, M. ;
Journe, F. ;
Marchant, A. ;
Jouffe, L. ;
Barillari, M. R. ;
Cammaroto, G. ;
Circiu, M. P. ;
Hans, S. ;
Saussez, S. .
JOURNAL OF INTERNAL MEDICINE, 2021, 290 (02) :451-461
[22]   Prevalence and 24-month recovery of olfactory dysfunction in COVID-19 patients: A multicentre prospective study [J].
Lechien, Jerome R. ;
Vaira, Luigi A. ;
Saussez, Sven .
JOURNAL OF INTERNAL MEDICINE, 2023, 293 (01) :82-90
[23]  
Leng M, 2013, J Softw Eng, V8, P14, DOI [DOI 10.3923/JSE.2014.14.22, 10.3923/jse.2014.14.22]
[24]   A 4-item measure of depression and anxiety: Validation and standardization of the Patient Health Questionnaire-4 (PHQ-4) in the general population [J].
Loewe, Bernd ;
Wahl, Inka ;
Rose, Matthias ;
Spitzer, Carsten ;
Glaesmer, Heide ;
Wingenfeld, Katja ;
Schneider, Antonius ;
Braehler, Elmar .
JOURNAL OF AFFECTIVE DISORDERS, 2010, 122 (1-2) :86-95
[25]   Correlation between olfactory function, age, sex, and cognitive reserve index in the Italian population [J].
Masala, Carla ;
Cavazzana, Annachiara ;
Sanna, Fabrizio ;
Cecchini, Maria Paola ;
Zanini, Alice ;
Gasperi, Flavia ;
Menghi, Leonardo ;
Endrizzi, Isabella ;
Borgogno, Monica ;
Drago, Serena ;
Cantone, Elena ;
Ciofalo, Andrea ;
Macchi, Alberto ;
Monti, Giulia ;
Parma, Valentina ;
Piochi, Maria ;
Pinna, Ilenia ;
Torri, Luisa ;
Cabrino, Giorgia ;
Ottaviano, Giancarlo ;
Pendolino, Alfonso Luca ;
Pignatelli, Angela ;
Pighin, Faride ;
Bochicchio, Vincenzo ;
Motta, Gaetano ;
Fontana, Giorgia ;
Pasquariello, Benedetta ;
Cavaliere, Carlo ;
Iacono, Valentina ;
Hummel, Thomas .
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2022, 279 (10) :4943-4952
[26]   Whose nose does not know? Demographical characterization of people unaware of anosmia [J].
Oleszkiewicz, Anna ;
Hummel, Thomas .
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2019, 276 (06) :1849-1852
[27]   Long-lasting olfactory dysfunction in COVID-19 patients [J].
Prem, Bernhard ;
Liu, David T. ;
Besser, Gerold ;
Sharma, Gunjan ;
Dultinger, Laura E. ;
Hofer, Sissy, V ;
Matiasczyk, Martina M. ;
Renner, Bertold ;
Mueller, Christian A. .
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2022, 279 (07) :3485-3492
[28]   Guideline S1: Long COVID: Diagnostics and treatment strategies [J].
Rabady, Susanne ;
Altenberger, Johann ;
Brose, Markus ;
Denk-Linnert, Doris-Maria ;
Fertl, Elisabeth ;
Goetzinger, Florian ;
Pellin, Maria de la Cruz Gomez ;
Hofbaur, Benedikt ;
Hoffmann, Kathryn ;
Hoffmann-Dorninger, Renate ;
Koczulla, Rembert ;
Lammel, Oliver ;
Lamprecht, Bernd ;
Loeffler-Ragg, Judith ;
Mueller, Christian A. ;
Poggenburg, Stefanie ;
Rittmannsberger, Hans ;
Sator, Paul ;
Strenger, Volker ;
Vonbank, Karin ;
Wancata, Johannes ;
Weber, Thomas ;
Weber, Joerg ;
Weiss, Guenter ;
Wendler, Maria ;
Zwick, Ralf-Harun .
WIENER KLINISCHE WOCHENSCHRIFT, 2021, 133 (SUPPL 7) :237-278
[29]   Neurological outcome and quality of life 3 months after COVID-19: A prospective observational cohort study [J].
Rass, Verena ;
Beer, Ronny ;
Schiefecker, Alois Josef ;
Kofler, Mario ;
Lindner, Anna ;
Mahlknecht, Philipp ;
Heim, Beatrice ;
Limmert, Victoria ;
Sahanic, Sabina ;
Pizzini, Alex ;
Sonnweber, Thomas ;
Tancevski, Ivan ;
Scherfler, Christoph ;
Zamarian, Laura ;
Bellmann-Weiler, Rosa ;
Weiss, Guenter ;
Djamshidian, Atbin ;
Kiechl, Stefan ;
Seppi, Klaus ;
Loeffler-Ragg, Judith ;
Pfausler, Bettina ;
Helbok, Raimund .
EUROPEAN JOURNAL OF NEUROLOGY, 2021, 28 (10) :3348-3359
[30]   Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case-control study of health workers [J].
Riestra-Ayora, Juan ;
Yanes-Diaz, Joaquin ;
Esteban-Sanchez, Jonathan ;
Vaduva, Cristina ;
Molina-Quiros, Cristina ;
Larran-Jimenez, Alba ;
Martin-Sanz, Eduardo .
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2021, 278 (12) :4831-4837