Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae

被引：6

作者：

Rass, Verena ^{[1
]}

Tymoszuk, Piotr ^{[2
]}

Sahanic, Sabina ^{[3
]}

Heim, Beatrice ^{[1
]}

Ausserhofer, Dietmar ^{[4
]}

Lindner, Anna ^{[1
]}

Kofler, Mario ^{[1
]}

Mahlknecht, Philipp ^{[1
]}

Boehm, Anna ^{[3
]}

Huefner, Katharina ^{[5
]}

Pizzini, Alex ^{[3
]}

Sonnweber, Thomas ^{[3
]}

Kurz, Katharina ^{[3
]}

Pfeifer, Bernhard ^{[6
,7
]}

Kiechl, Stefan ^{[1
]}

Peball, Marina ^{[1
]}

Kindl, Philipp ^{[1
]}

Putnina, Lauma ^{[1
]}

Fava, Elena ^{[1
]}

Djamshidian, Atbin ^{[1
]}

Huber, Andreas ^{[6
]}

Wiedermann, Christian J. ^{[4
]}

Sperner-Unterweger, Barbara ^{[5
]}

Woell, Ewald ^{[8
]}

Beer, Ronny ^{[1
]}

Schiefecker, Alois Josef ^{[1
]}

Bellmann-Weiler, Rosa ^{[3
]}

Bachler, Herbert ^{[9
]}

Tancevski, Ivan ^{[3
]}

Pfausler, Bettina ^{[1
]}

Piccoliori, Giuliano ^{[4
]}

Seppi, Klaus ^{[1
]}

Weiss, Guenter ^{[3
]}

Loeffler-Ragg, Judith ^{[3
]}

Helbok, Raimund ^{[1
,10
]}

机构：

[1] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria

[2] Data Analyt Serv Tirol, Innsbruck, Austria

[3] Med Univ Innsbruck, Dept Internal Med 2, Innsbruck, Austria

[4] Claudiana Coll Hlth Profess, Inst Gen Practice & Publ Hlth, Bolzano, Italy

[5] Med Univ Innsbruck, Univ Hosp Psychiat 2, Dept Psychiat Psychotherapy Psychosomat & Med Psy, Innsbruck, Austria

[6] Tyrolean Fed Inst Integrated Care, Innsbruck, Austria

[7] UMIT, Div Hlth Networking & Telehlth Biomed Informat &, Hall In Tirol, Austria

[8] St Vinzenz Hosp, Dept Internal Med, Zams, Austria

[9] Med Univ Innsbruck, Inst Gen Med, Innsbruck, Austria

[10] Johannes Kepler Univ Linz, Dept Neurol, Linz, Austria

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2023年 / 280卷 / 11期

关键词：

Olfactory dysfunction; Smell and taste disorder; Long COVID; Post-COVID-19; condition; Mental health; Quality of life;

D O I：

10.1007/s00405-023-08163-x

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

PurposeOlfactory dysfunction (OD) commonly accompanies coronavirus disease 2019 (COVID-19). We investigated the kinetics of OD resolution following SARS-CoV-2 infection (wild-type and alpha variant) and its impact on quality of life, physical and mental health.MethodsOD prevalence was assessed in an ambulatory COVID-19 survey (n = 906, >= 90 days follow-up) and an observational cohort of ambulatory and hospitalized individuals (n = 108, 360 days follow-up). Co-occurrence of OD with other symptoms and effects on quality of life, physical and mental health were analyzed by multi-dimensional scaling, association rule mining and semi-supervised clustering.ResultsBoth in the ambulatory COVID-19 survey study (72%) and the observational ambulatory and hospitalized cohort (41%) self-reported OD was frequent during acute COVID-19. Recovery from self-reported OD was slow (survey: median 28 days, observational cohort: 90 days). By clustering of the survey data, we identified a predominantly young, female, comorbidity-free group of convalescents with persistent OD and taste disorders (median recovery: 90 days) but low frequency of post-acute fatigue, respiratory or neurocognitive symptoms. This smell and taste disorder cluster was characterized by a high rating of physical performance, mental health, and quality of life as compared with convalescents affected by prolonged fatigue or neurocognitive complaints.ConclusionOur results underline the heterogeneity of post-acute COVID-19 sequelae calling for tailored management strategies. The persistent smell and taste disorder phenotype is characterized by good clinical, physical, and mental recovery and may pose a minor challenge for public health.Study registrationClinicalTrials.gov: NCT04661462 (survey study), NCT04416100 (observational cohort).

引用

页码：5115 / 5128

页数：14

共 45 条

[1]

Agrawal R., 1993, SIGMOD Record, V22, P207, DOI 10.1145/170036.170072

[2] Modified Olfactory Training Is an Effective Treatment Method for COVID-19 Induced Parosmia [J].