Oxymatrine Alleviates Collagen-Induced Arthritis in Mice by Regulating the Immune Balance of T Cells

被引：5
作者：
Cao, Gan [1 ]
Li, Jing [1 ]
Mao, Zhuhan [1 ]
Zhang, Yanli [1 ]
机构：
[1] Ningxia Med Univ, Sch Basic Med Sci, Dept Pathogen Biol & Immunol, Yinchuan 750004, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 15期
基金：
中国国家自然科学基金;
关键词：
gut microbiota; Th cell; oxymatrine;
D O I：
10.3390/molecules28155879
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic immunity and autoimmune disorders. We have previously found that oxymatrine (OMT), a natural alkaloid, can alleviate rheumatoid arthritis without knowing whether OMT can alleviate rheumatoid arthritis through gut microbiota. In this study, we found that OMT can alleviate collagen-induced arthritis in mice and reconstruct the immune balance of Th1/Th2, Treg/Th17, and Tfr/Tfh cells. Colon transcriptome gene enrichment analysis indicated that oxymatrine may alleviate collagen induced arthritis in mice through immune system process pathway. Furthermore, OMT significantly altered the gut microbiota variety, changed the composition of microbial colonies, and reshaped the gut microbiota of collagen-induced arthritis (CIA) mice, which may participate in the regulation of the balance of Th1/Th2, Treg/Th17, and Tfr/Tfh cells to alleviate collagen-induced arthritis in mice.
引用
收藏
页数：12
相关论文
共 28 条
[1]   Enhancing Antibiotics Efficacy by Combination of Kuraridin and Epicatechin Gallate with Antimicrobials against Methicillin-Resistant Staphylococcus aureus [J].
Chan, Ben Chung-Lap ;
Barua, Nilakshi ;
Lau, Clara Bik-San ;
Leung, Ping-Chung ;
Fung, Kwok-Pui ;
Ip, Margaret .
ANTIBIOTICS-BASEL, 2023, 12 (01)
[2]   MicroRNA-Mediated Epigenetic Regulation of Rheumatoid Arthritis Susceptibility and Pathogenesis [J].
Chang, Cen ;
Xu, Lingxia ;
Zhang, Runrun ;
Jin, Yehua ;
Jiang, Ping ;
Wei, Kai ;
Xu, Linshuai ;
Shi, Yiming ;
Zhao, Jianan ;
Xiong, Momiao ;
Guo, Shicheng ;
He, Dongyi .
FRONTIERS IN IMMUNOLOGY, 2022, 13
[3]   Multi-omics profiling reveals potential alterations in rheumatoid arthritis with different disease activity levels [J].
Chen, Jianghua ;
Li, Shilin ;
Zhu, Jing ;
Su, Wei ;
Jian, Congcong ;
Zhang, Jie ;
Wu, Jianhong ;
Wang, Tingting ;
Zhang, Weihua ;
Zeng, Fanwei ;
Chang, Shengjia ;
Jia, Lihua ;
Su, Jiang ;
Zhao, Yi ;
Wang, Jing ;
Zeng, Fanxin .
ARTHRITIS RESEARCH & THERAPY, 2023, 25 (01)
[4]   Gut Microbiota, Immune System, and Bone [J].
D'Amelio, P. ;
Sassi, F. .
CALCIFIED TISSUE INTERNATIONAL, 2018, 102 (04) :415-425
[5]   Follicular regulatory T cells produce neuritin to regulate B cells [J].
Gonzalez-Figueroa, Paula ;
Roco, Jonathan A. ;
Papa, Ilenia ;
Villacis, Lorena Nunez ;
Stanley, Maurice ;
Linterman, Michelle A. ;
Dent, Alexander ;
Canete, Pablo F. ;
Vinuesa, Carola G. .
CELL, 2021, 184 (07) :1775-+
[6]   Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis [J].
Horta-Baas, Gabriel ;
del Socorro Romero-Figueroa, Maria ;
Jose Montiel-Jarquin, Alvaro ;
Luisa Pizano-Zarate, Maria ;
Garcia-Mena, Jaime ;
Ramirez-Duran, Ninfa .
JOURNAL OF IMMUNOLOGY RESEARCH, 2017, 2017
[7]   Effects of Sophora flavescens aiton and the absorbed bioactive metabolite matrine individually and in combination with 5-fluorouracil on proliferation and apoptosis of gastric cancer cells in nude mice [J].
Hu, Huan-Fu ;
Wang, Zheng ;
Tang, Wen-Li ;
Fu, Xue-Ming ;
Kong, Xiang-Jun ;
Qiu, Ying-Kun ;
Xi, Sheng-Yan .
FRONTIERS IN PHARMACOLOGY, 2022, 13
[8]   Matrine regulates Th1/Th2 inflammatory responses by inhibiting the Hsp90/NF-κB signaling axis to alleviate atopic dermatitis [J].
Huang, Pan ;
Hu, Fan ;
Yang, Zhi-Bo ;
Pan, Yi ;
Zhou, Rong ;
Yan, Yi-Ning ;
Wang, Hai-Zhen ;
Wang, Chang .
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2023, 39 (05) :501-510
[9]   Function and Role of Regulatory T Cells in Rheumatoid Arthritis [J].
Jiang, Qi ;
Yang, Guocan ;
Liu, Qi ;
Wang, Shengjun ;
Cui, Dawei .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[10]   Lycium barbarum polysaccharide modulates gut microbiota to alleviate rheumatoid arthritis in a rat model [J].
Lai, Wenjia ;
Wang, Chunyan ;
Lai, Renfa ;
Peng, Xichun ;
Luo, Jianming .
NPJ SCIENCE OF FOOD, 2022, 6 (01)
123