Three new isocoumarin analogues from an endolichenic fungus Aspergillus flavus CPCC 400810

被引：2

作者：

Wang, Ren-Zhong ^{[1
,2
]}

Su, Bing-Jie ^{[2
]}

Chen, Yu-Chuan ^{[2
]}

Xiao, Tong-Mei ^{[2
]}

Yan, Bi-Ying ^{[2
]}

Yu, Li-Yan ^{[2
]}

Si, Shu-Yi ^{[2
]}

Wu, De-Ling ^{[1
]}

Chen, Ming-Hua ^{[2
]}

机构：

[1] Anhui Univ Chinese Med, Sch Pharm, Dept Tradit Chinese Med & Nat Med Chem, Hefei, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 17期

关键词：

Isocoumarin; Aspergillus flavus CPCC 400810; endolichenic fungus;

D O I：

10.1080/14786419.2023.2209820

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Five isocoumarin derivatives including three new compounds, aspermarolides A-C (1-3), and two known analogues, 8-methoxyldiaporthin (4) and diaporthin (5) were obtained from the culture extract of Aspergillus flavus CPCC 400810. The structures of these compounds were elucidated by spectroscopic methods. The double bond geometry of 1 and 2 were assigned by the coupling constants. The absolute configuration of 3 was determined by electronic circular dichroism experiment. All compounds showed no cytotoxic activities against the two human cancer cells HepG2 and Hela.

引用

页码：3021 / 3027

页数：7

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