Anti-inflammatory activities of triterpenoids from Euphorbia humifusa Willd

被引：1

作者：

Huang, Pei-Zhi ^{[1
]}

Yang, Hong-Ying ^{[1
]}

Zhang, Lan-Jun ^{[1
]}

Sun, Yue ^{[1
]}

Li, Ya ^{[1
]}

Gao, Kun ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2023年 / 54卷

基金：

中国国家自然科学基金;

关键词：

Triterpenoids; Anti-inflammatory activity; Euphorbia humifusa Willd; FERNANE;

D O I：

10.1016/j.phytol.2023.02.003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigation of the whole herbs of Euphorbia humifusa Willd. led to the isolation of two unde-scribed triterpenoids, (3S,5R,7R,8S,10S,13S,14S,17R,18R,21R)-7 alpha,8 alpha-epoxyfern-9(11)-en-3 beta-ol (1) and (3R, 7R,8S,9S,13S,14S,17R,18R,21R)-7 alpha,8 alpha-epoxyadian-5(10)-en-3 alpha-ol (2), along with three known compounds 3-5. Their structures were elucidated by spectroscopic analysis and optical rotation calculations. All isolates were screened for their anti-inflammatory activity by evaluating their inhibitory effect on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 1, 2, 4, and 5 showed potent inhibitory effects on LPS-induced NO production with IC50 values ranging from 18.88 to 31.77 mu M.

引用

页码：129 / 132

页数：4

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