Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint

被引:8
作者
Yang, Benyi [1 ]
Li, Xin [2 ,3 ]
Fu, Chaoran [1 ]
Cai, Wenyi [2 ,3 ]
Meng, Bowen [1 ]
Qu, Yan [1 ]
Kou, Xiaoxing [1 ]
Zhang, Qingbin [2 ,3 ]
机构
[1] Sun Yat Sen Univ, Guangdong Prov Key Lab Stomatol, South China Ctr Craniofacial Stem Cell Res, Guanghua Sch Stomatol,Hosp Stomatol, Guangzhou, Peoples R China
[2] Guangzhou Med Univ, Affiliated Stomatol Hosp, Dept Temporomandibular Joint, Guangzhou, Peoples R China
[3] Guangdong Engn Res Ctr Oral Restorat & Reconstruct, Guangzhou Key Lab Basic & Appl Res Oral Regenerat, Guangzhou, Peoples R China
来源
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
osteoarthritis; TMJ; peripheral joint; extracellular vesicles; EV therapy; MESENCHYMAL STEM-CELLS; PLATELET-RICH PLASMA; ARTICULAR-CARTILAGE VESICLES; KNEE OSTEOARTHRITIS; SUBCHONDRAL BONE; SYNOVIAL-FLUID; EXOSOMES; APOPTOSIS; DIAGNOSIS; BIOGENESIS;
D O I
10.3389/fendo.2023.1158744
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Osteoarthritis (OA) is a disabling disease with significant morbidity worldwide. OA attacks the large synovial joint, including the peripheral joints and temporomandibular joint (TMJ). As a representative of peripheral joint OA, knee OA shares similar symptoms with TMJ OA. However, these two joints also display differences based on their distinct development, anatomy, and physiology. Extracellular vesicles (EVs) are phospholipid bilayer nanoparticles, including exosomes, microvesicles, and apoptotic bodies. EVs contain proteins, lipids, DNA, micro-RNA, and mRNA that regulate tissue homeostasis and cell-to-cell communication, which play an essential role in the progression and treatment of OA. They are likely to partake in mechanical response, extracellular matrix degradation, and inflammatory regulation during OA. More evidence has shown that synovial fluid and synovium-derived EVs may serve as OA biomarkers. More importantly, mesenchymal stem cell-derived EV shows a therapeutic effect on OA. However, the different function of EVs in these two joints is largely unknown based on their distinct biological characteristic. Here, we reviewed the effects of EVs in OA progression and compared the difference between the knee joint and TMJ, and summarized their potential therapeutic role in the treatment of OA.
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页数:13
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