Poly-ADP-ribose polymerase (PARP) inhibitors and ovarian function

被引：14

作者：

Li, Jiajia ^{[1
,2
]}

Li, Qingchao ^{[2
]}

Zhang, Lingyi ^{[2
,3
]}

Zhang, Songling ^{[1
]}

Dai, Yun ^{[2
]}

机构：

[1] First Hosp Jilin Univ, Dept Gynecol Oncol, 71 Xinmin St, Changchun 130012, Jilin, Peoples R China

[2] First Hosp Jilin Univ, Lab Canc Precis Med, 519 Dong Min Zhu St, Changchun 130061, Jilin, Peoples R China

[3] Second Hosp Jilin Univ, Dept Gynecol & Obstet, Changchun, Jilin, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 157卷

基金：

中国国家自然科学基金;

关键词：

PARP inhibitor; Ovarian function; Fertility; BRCA mutation; DNA repair; RADIATION; RESERVE; POLY(ADP-RIBOSYL)ATION; INSUFFICIENCY; ASSOCIATION; ACTIVATION; MUTATIONS; APOPTOSIS; FIBROSIS; FAILURE;

D O I：

10.1016/j.biopha.2022.114028

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Poly-ADP-ribose polymerase (PARP) plays an important role in DNA damage detection and repair. PARP inhibitors (PARPi) are a novel class of targeted agents used widely in the treatment of female cancer patients with BRCA mutations, including younger patients. However, the impact of PARPi on ovarian function remains a considerable problem in clinical practice. In this review article, we summarize the current understanding of PARPi's effects on the function of ovary and discuss their potential underlying mechanisms, highlighting the significance of further investigation on the criterion for ovarian failure and its preventive approaches during PARPi treatment.

引用

页数：6

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