Efficacy of sequential chemoradiotherapy combined with toripalimab in de novo metastatic nasopharyngeal carcinoma: A phase II trial

被引：12

作者：

Chen, Si-Yuan ^{[1
,2
]}

Duan, Xiao-Tong ^{[1
,2
]}

Li, Hui-Feng ^{[1
,2
]}

Peng, Lan ^{[1
,2
]}

Wang, Zhi-Qiang ^{[3
]}

Xu, Gui-Qiong ^{[4
]}

Hua, Yi-Jun ^{[1
,2
]}

Zou, Xiong ^{[1
,2
]}

You, Rui ^{[1
,2
]}

Ouyang, Yan-Feng ^{[1
,2
]}

Liu, You-Ping ^{[1
,2
,5
]}

Gu, Chen-Mei ^{[1
,2
]}

Yang, Qi ^{[1
,2
]}

Jiang, Rou ^{[1
,2
]}

Zhang, Meng-Xia ^{[1
,2
]}

Lin, Mei ^{[1
,2
]}

Xie, Yu-Long ^{[1
,2
]}

Lin, Chao ^{[1
,2
]}

Ding, Xi ^{[1
,2
]}

Xie, Ruo-Qi ^{[1
,2
]}

Duan, Chong-Yang ^{[6
]}

Zhang, Wei-Jing ^{[2
,7
]}

Huang, Pei-Yu ^{[1
,2
]}

Chen, Ming-Yuan ^{[1
,2
,5
]}

机构：

[1] Sun Yat Sen Univ, Dept Nasopharyngeal Carcinoma, Canc Ctr, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Guangdong Key Lab Nasopharyngeal Carcinoma Diag &, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Guangdong, Peoples R China

[3] Kunming Med Univ, Dept Psychiat, Affiliated Hosp 1, Kunming 650000, Yunnan, Peoples R China

[4] Zhongshan City Peoples Hosp, Dept Head & Neck Carcinoma & Radiotherapy, Zhongshan 528400, Guangdong, Peoples R China

[5] Sun Yat Sen Univ, NanChang Hosp, Nasopharyngeal Canc Ctr, Hosp Nanchang 1, Nanchang, Jiangxi, Peoples R China

[6] Southern Med Univ, Sch Publ Hlth, Dept Biostat, Guangzhou 510000, Guangdong, Peoples R China

[7] Sun Yat sen Univ, Dept Radiol, Canc Ctr, Guangzhou 510000, Guangdong, Peoples R China

来源：

CELL REPORTS MEDICINE | 2023年 / 4卷 / 11期

基金：

中国国家自然科学基金;

关键词：

DISTANT METASTASIS; 1ST-LINE TREATMENT; ANTITUMOR-ACTIVITY; RECURRENT; MULTICENTER; CHEMOTHERAPY; CISPLATIN; CANCER; SAFETY;

D O I：

10.1016/j.xcrm.2023.101279

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Locoregional radiotherapy added to chemotherapy has significantly improved survival in de novo metastatic nasopharyngeal carcinoma (mNPC). However, only 54% of de novo mNPC patients who received sequential chemoradiotherapy have complete or partial response 3 months after radiotherapy. This Simon's optimal two-stage design phase II study (NCT04398056) investigates whether PD-1 inhibitor could improve tumor control in combination with chemoradiation. The primary endpoint is objective response rate (ORR) at 3 months after radiotherapy. Twenty-two patients with primary mNPC are enrolled. The ORR at 3 months after radiotherapy is 81.8% (22.7% complete response, n = 5; 59.1% partial response, n =13), and the disease control rate is 81.8%. The 3-year progression-free survival (PFS) rate is 44.9% (95% confidence interval 26.4%- 76.3%). Fifteen patients (68.2%) experienced grade 3-4 adverse events. Patients with high baseline plasma Epstein-Barr virus DNA copy number (>10(4) cps/mL) show worse PFS. Addition of toripalimab to sequential chemoradiotherapy suggests promising tumor response in patients with primary mNPC.

引用

页数：11

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