The risk factors of early arterial stiffness in type 2 diabetes without diabetic macroangiopathy

BackgroundType 2 diabetes exposes the body to a state of high blood sugar for a long time and causes varying degrees of hardening of the arteries, making it more prone to cardiovascular emergencies.ObjectiveThe aim of the study was to explore the risk factors of early arterial stiffness in patients with type 2 diabetes mellitus (T2DM).MethodsA retrospective study was conducted on 316 T2DM patients without macroangiopathy in The First Hospital of Qinhuangdao. Early arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV).ResultsNinety patients (28.5%) had baPWV & GE;1800cm/s. baPWV showed positive correlation with systolic blood pressure (r=0.456, p<0.001), diastolic blood pressure (r=0.133, p=0.018), urine albumin-creatinine ratio (UACR) (r=0.232, p<0.001), neutrophil lymphocyte ratio (NLR) (r=0.185, p=0.001), and visceral fat area (r=0.139, p=0.014). In multiple linear regression analysis, systolic blood pressure (& beta;=6.240, p<0.001), UACR (& beta;=3.805, p=0.019), NLR (& beta;=43.722, p=0.013), and visceral fat area (& beta;=0.778, p=0.030) were significant independent predictors for baPWV.ConclusionThe decline of arterial elasticity was common in T2DM patients without macroangiopathy. Elevated blood pressure, microangiopathy, chronic inflammation, and visceral fat accumulation were the risk factors of early arterial stiffness in patients with T2DM.